丹参葡萄糖注射液的急性毒性和局部用药毒性研究  

Study on acute and topical toxicity of Danshen glucose injection

作　　者：杨解人[1] 桂常青[1] 熊莺[1] 陈国祥[1] 丁伯平[1] 宋建国[1] 

机构地区：[1]皖南医学院药理学教研室,安徽芜湖241001

出　　处：《皖南医学院学报》2007年第1期11-14,共4页Journal of Wannan Medical College

摘　　要：目的:观察丹参葡萄糖注射液(丹参)的急性毒性及局部用药毒性。方法:Bliss法测定小鼠及大鼠LD50;家兔耳缘静脉滴注法、体外红细胞悬液致溶血和凝集试验、血管刺激性试验及豚鼠致敏试验观察局部用药毒性。结果:大、小鼠尾静脉注射丹参的LD50分别为27.02g/kg和26.89g/kg,小鼠i.p为36.09g/kg。家兔i.v5d无明显刺激性;豚鼠未见过敏反应;体外不同浓度丹参对家兔红细胞悬液无致溶血及凝集作用。结论:丹参急性毒性很小,无明显局部用药毒性反应。Objective ：To observe the acute and topical toxicity of administering Danshen glucose injection（DGI）. Methods： LD50 of DGI was determined by Bliss method in rats and mice, and topical toxicity survey was conducted with intravenous drip of rabbit auri-fringe, by vitro red cell suspension haematolysis and agglutination test. Both blood vessel irritation test and cavy sensitization test were employed for this purpose as well. Results ：The LD50 of DGI was observed ranging from 26.89 g/kg for i. v to 36.09 g/kg for i. p in mice, and that of i.v. 27.02 g/kg was seen in rats. There was no obvious irritation with rabbits in a session of 5-day i.v. or allergic response with envy. The results also revealed that concentration variation of DGI produced no effect on haematolysis and agglutination of red cell suspension in vitro. Conclusion： The findings suggest that DGI will produce less acute toxicity with no topical toxic reaction.

关 键 词：丹参葡萄糖注射液 急性毒性 刺激性 过敏反应 反应 

分 类 号：R289.5[医药卫生—方剂学]