施他宁 善得定及垂体后叶素治疗AGVB的疗效对比  

Efficacy and safety of somatostatin and its derivative versus pituitrin in patients with acute gastroesophageal variceal bleeding

作　　者：林志鹏[1] 林琪[1] 林万朝[1] 施子诺[1] 

机构地区：[1]泉州市第一医院,福建泉州362000

出　　处：《现代医药卫生》2007年第5期643-645,共3页Journal of Modern Medicine & Health

摘　　要：目的:评价施他宁、善得定、垂体后叶素治疗急性食管胃底静脉曲张破裂出血(AGVB)的疗效和不良反应。方法:选择57例肝硬化并AGVB患者随机分为3组,分别使用施他宁、善得定、垂体后叶素治疗,记录3组的止血效果和不良反应。结果:施他宁、善得定和垂体后叶素均能有效控制AGVB,治疗总有效率分别为82.61%、81.25%、77.78%,组间比较差异无显著性(P>0.05)。施他宁组和善得定组仅有轻微不良反应。结论:施他宁、善得定治疗AGVB的疗效与垂体后叶素差异无显著性,但在无正确的禁忌证应首选垂体后叶素。Objective：To assess the efficacy and safety of somatostatin and its derivative in the treatment of acute gastroesophageal variceal bleeding（AGVB）.Methods：Fifty-seven patients with AGVB were randomly divied into 3 groups,which received either stilamin（n= 23） or sandostatin （n=16） or pituitrin （n=18） respectively.The results of hemostasis and all side effects were recorded throughout therapy. Results：All stilamin,sandostatin and pituitrin were effective in controlling AGVB.82.61%,81.25% and 77.78% of patients in each group were considered to be effective with no statistically significant difference （P〉0.05） among the three groups.Both stilamin and sandostatin had mild adverse effects.Conclusion：The efficacy of somatostatin and its derivative was similar to pituitrin in controlling AGVB due to cirrhosis,but their toleration and safety were superior to pituitrin.

关 键 词：施他宁 善得定 垂体后叶素 急性食管胃底静脉曲张破裂出血 

分 类 号：R5[医药卫生—内科学]