灯心草酚性成分的分离与结构鉴定  

Isolation and identification of phenolic constituents from Juncus effusus

作　　者：李红霞[1] 邓铁忠[1] 陈玉[2] 冯慧谨[3] 杨光忠[1] 

机构地区：[1]中南民族大学生命科学学院 [2]中南民族大学化学与材料学院,湖北武汉430074 [3]中国科学院上海生命科学院上海药物研究所,上海201203

出　　处：《药学学报》2007年第2期174-178,共5页Acta Pharmaceutica Sinica

基　　金：湖北省自然科学基金资助项目(2005ABA071);教育部留学回国人员科研启动费资助项目.

摘　　要：为研究灯心草科灯心草属植物灯心草(Juncus effususL.)干燥茎髓中的酚性成分,运用正相和反相硅胶柱色谱法对灯心草乙酸乙酯部位进行分离纯化,并用波谱技术鉴定化合物结构。共分离得到6个酚性成分,其结构分别鉴定为7-羧基-2-羟基-1-甲基-5-乙烯基-9,10-二氢菲(1),2,3-异丙叉-1-O-阿魏酰甘油酯(2),(2S)-2,3-异丙叉-1-O-对羟基桂皮酰甘油酯(3),dehydroeffusal(4),对羟基苯甲醛(5)和毛地黄黄酮-5,3′-二甲酯(6)。其中化合物1和2为新化合物,化合物5和6为首次从该属植物中分得,本文首次报道了化合物6的13C NMR数据。To study the phenolic constituents from the dry stem of Juncus effusus L. , the constituents were isolated by normal-phase and reverse-phase silica gel column chromatography from the EtOAc extract. Their structures were elucidated by spectral analysis. Six phenolic constituents were purified and identified as 7-carboxy-2-hydroxy-1-methyl-5-vinyl-9,10-dihydrophenanthrene （1）, 2,3-isopylidene-1-O-ferulic acid glyceride （ 2 ） , （ 2S ）-2, 3-isopylidene-1-O-p-coumaroyl glyceride （ 3 ） , dehydroeffusal （ 4 ） , p- hydroxybenzaldehyde （5） and luteolin-5,3＇-dimethyl ether （6）. Compounds 1 and 2 are new compounds. Compounds 5 and 6 were isolated from Juncaceae plant for the first time. ^13C NMR data of compound 6 were reported for the first time.

关 键 词：灯心草科 灯心草 酚性成分 

分 类 号：R284.1[医药卫生—中药学] R284.2[医药卫生—中医学]