依诺沙星的荷移分光光度法测定  

Spectrophotometric Determination of Enoxacin Based on Charge Transfer Reaction

作　　者：陶玉龙[1] 敖登高娃[1] 周兴军[1] 阿娟[2] 

机构地区：[1]内蒙古大学化学化工学院,呼和浩特010021 [2]内蒙古农业大学理学院,呼和浩特010019

出　　处：《分析科学学报》2007年第1期122-124,共3页Journal of Analytical Science

基　　金：内蒙古教育厅自然科学基金(No.NJ05040)

摘　　要：研究了电子给体依诺沙星（Enoxacin，ENX）与电子受体茜素红（Allzarin Red，AR）之间的电荷转移反应，确定了反应的最佳条件。实验结果表明：ENX与AR在水溶液中，于室温下即可生成稳定的1：2络合物。该络合物的λmax=524nm，表观摩尔吸光系数是6．96×10^3L·mol^-1·cm^-1，依诺沙星浓度在0～20mg／L范围内符合比耳定律，相对标准偏差为0．250A（n=11）。方法用于测定药物制剂中依诺沙星的含量，其回收率为99．49／6～100．5％。The charge-transfer（CT） reaction between enoxacin as the electron donor and alizarin red as the electron acceptor has been studied by spectrophotometric method . The results indicated that in water solution enoxacin can form charge transfer complex with alizarin red, the composition ratio was 1：2, Amax was at 524 nm, the apparent molar absorptivity of the complex was 6.96×10^3 L·mol^-1 ·cm^-1, the absorbance was linearly related to the concentration of enoxacin in the range of 0-20 mg/L with a detection limit of 0.4 mg/L, the relative standard deviation was 0.25% （n=11） . The proposed method has been applied to the determination of enoxacin in tablets and capsules with satisfactory results. The recoveries of enoxacin were 99.4%-100. 5%.

关 键 词：荷移反应 分光光度法 依诺沙星 茜素红 

分 类 号：O657.32[理学—分析化学]