游离脂肪酸在高血压伴代谢综合征发病机制中的作用探讨  

Study on the role of free fatty acid in the mechanism of hypertension accompanied with metabolic syndrome

作　　者：余小平[1] 曲环[1] 杨海涛[1] 李晓苏[1] 刘茜倩[1] 李秋荣[1] 

机构地区：[1]北京大学深圳医院心内科,广东省518036

出　　处：《中国心血管病研究》2007年第2期97-99,共3页Chinese Journal of Cardiovascular Research

摘　　要：目的了解血清游离脂肪酸(FFA)在高血压伴代谢综合征(MS)发病机制中的作用。方法选取高血压伴MS、单纯高血压、健康人群各50例。检测所有对象的FFA、体重指数(BMI)、腰臀比(WHR)和外周胰岛素敏感度(SI)等指标。结果①MS高血压病组的血清FFA高于单纯高血压组及健康对照组(P<0.05)。②血清FFA与SI呈负相关(r=-0.785,P<0.05),与BMI、WHR、收缩压(SBP)呈正相关(r分别为0.801、0.856,P<0.05)。结论高血压伴MS患者的高血清FFA与胰岛素抵抗并存,并有可能是引起高血压伴MS患者其他病理生理改变的主要机制。Objective To explore the role of free fatty acid （FFA） in the mechanism of hypertension accompanied metabolic syndrome. Methods One hundred and fifty objects were divided into three groups. They were hypertension with MS group, hypertension group, and health control group. Everyone in the study were tested the following parameters： serum FFA, BMI,WHR and SI. Results （1）FFA concentration in serum of hypertension with MS patients was higher than those of the other two groups（P〈0.05）. （2）Tbere was negative correlation between serum FFA and SI （r=-0.785,P〈0.05）. While there was positive correlation between serum FFA and MBI, WHR and SP （The value of r were 0.801,0.856,0.872 respectively, all P〈0.05）. Conclusion There exits both high concentration FFA and insulin resistance in the patients who suffer from hypertension with MS. Maybe both of the two conditions are the main mechanism of the disease.

关 键 词：脂肪酸类 非脂化 高血压 代谢综合征X 

分 类 号：R544.1[医药卫生—心血管疾病] R442.8[医药卫生—内科学]