白术对动物胃肠运动的作用及其机制的探讨  

Effects and mechanism of rhizoma atractylodis macrocephalae on gastrointes- tinal motility in animals

作　　者：马晓松[1] 樊雪萍[1] 陈忠[1] 李崇文[1] 邢善 

机构地区：[1]广州医学院生理教研室,第一军医大学珠江医院

出　　处：《中华消化杂志》1996年第5期261-264,共4页Chinese Journal of Digestion

摘　　要：目的：观察白术对动物胃肠运动的影响并探讨其作用机制。材料与方法：以豚鼠回肠收缩强度为指标，观察不同浓度的白术水煎剂对肠平滑肌收缩的影响；用碳末胶液在小鼠小肠内推进的距离占小肠全长百分数为指标，观察白术对小鼠胃肠推进运动的影响。结果：浓度为０．ｌμｍ的白术水煎剂１．０ｍｌ可轻度抑制回肠的收缩；较大浓度的白术水煎剂１μｍ、１０μｍ、０．１μｍ、１ｍＭ、１０ｍＭ则能显著加强回肠的收缩，并呈量效反应关系。０．１ｍｇ／１０ｇ体重的白术煎剂对小鼠胃肠推进运动有显著加强作用；阿托品能明显抑制白术的兴奋作用；酚妥拉明可部分拮抗白术的兴奋效应；心得安对白术的兴奋效应影响不大。结论：大剂量白术水煎剂能促进动物的胃肠运动，随剂量加大而作用加强。这种效应主要通过胆碱能受体介导，α受体可能通过某种间接途径参与其调节机制．Purpose:To study the effect and mcehanism of Rhizoma atractylodis macrocephalae(RAM)on gastrointestinal motility in animals. Materials and methods:The varied concentrations of RAM on the spontaneous contraction of isolated guinea pig ileum was studied;The effect of RAM on the gastrointestinal propulsive movementwas assessed by the travelled distance of colloidal charcoal powder along the smallintestine in mice. Results:RAM 6.25%inhibited modestly the spontaneous contraction;RAM I2.5% or higher concentrations could significantly augment the spontaneouscontraction and was dose-dependent.RAM 0.1ml/10g weight increased markedly thepropulsive movement but was abolished by atropine; Regitine antagoniaed theincreased gastrointestinal propulsive movement and Propranolol had no effect onRAM. Conclusion∶ RAM has a stimulating effect on the propulsive movement ofgastrointestinal tract,which may be mediated through M recpetor or indirectly thealpha receptor.

关 键 词：白术 中医药疗法 胃肠推进运动 胃肠功能紊乱 

分 类 号：R259.570.5[医药卫生—中西医结合]