单次静脉注射曲马多超前镇痛用于胆囊切除术病人的效果评估  

Evaluation of the effect of preemptive analgesia with intravenous administration of tramadol in cholecystectomy

作　　者：孙建良[1] 屠海林[1] 周煦燕[1] 周咏华[1] 陆雅萍[1] 黄兵[1] 

机构地区：[1]浙江省嘉兴市第一医院麻醉科,嘉兴314000

出　　处：《临床医学》2007年第1期9-10,共2页Clinical Medicine

摘　　要：目的评估胆囊切除手术前静脉应用曲马多的超前镇痛效应。方法ASAⅠ-Ⅱ级拟在全麻下行胆囊切除手术的60例患者随机分为两组，每组30例。观察组（超前镇痛组）切皮前10min静脉给予曲马多3mg／kg＋地塞米松7．5mg，共10ml。对照组切皮前10min静脉给予等渗盐水＋地塞米松7．5mg，共10ml。观察术后12h的镇痛效果和疼痛评分（VAS）。结果观察组术后12h的镇痛效果显著优于对照组，疼痛评分（VAS）显著低于对照组（P〈0．05）。结论胆囊切除手术前预先给予曲马多可产生良好的超前镇痛效果。Objective To evaluate the preemptive analgesia of intravenous tramadol preoperatively in cholecystectomy. Methotis Sixty ASA Ⅰ or Ⅱpatients undergoing cholecystectomy under general anesthesia were randomly divided into 2 groups （ 30 cases/group）. In group P （ group preemptive ） intravenous tramadol （ 3 mg/kg） and dexamethasone （ 7.5 rag） were administrated as a bolus dose 10 min prior to skin incision. Group C（ group control） received saline and dexamethasone（7.5 rag） as a placebo. The pain score（VAS）and effect of analgesia in 12 h after operation were obtained. Results The VAS postoperative was markedly lower and the effect of analgesia was better in group P compared to group C in 12 h after operation（ P 〈 0.05 ）. Condusion Intravenous tramadol as a bolus dose of 3 mg/kg may provide reliable preemptive analgesia in cholecystectomy.

关 键 词：超前镇痛 胆囊切除手术 曲马多 

分 类 号：R657.4[医药卫生—外科学] R614[医药卫生—临床医学]