肠内营养对克罗恩病血清二胺氧化酶的影响及机制研究  

Effects of enteral nutrition on the plasma diamine oxidase activities in Crohn's disease

作　　者：陶庆松[1] 任建安[1] 于宝军[1] 王新波[1] 范朝刚[1] 黎介寿[1] 

机构地区：[1]南京大学医学院临床学院(南京军区南京总医院)解放军普通外科研究所,江苏南京210002

出　　处：《肠外与肠内营养》2007年第1期18-20,共3页Parenteral & Enteral Nutrition

基　　金：江苏省自然科学基金重大项目资助(BK2006719)

摘　　要：目的:动态观察肠内营养对活动期克罗恩病(CD)病人血清二胺氧化酶(DAO)活性的影响及其机制研究。方法:38例活动期克罗恩病病人,单独给予全肠内营养支持,观察肠内营养使用后第2、4周血清DAO水平的变化,并同步观察血清清蛋白(ALB)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-1β(IL-1β)和IL-6的变化。以53例健康志愿者的血清DAO水平为正常对照。结果:在使用肠内营养前,CD病人血清DAO活性显著低于健康志愿者;使用后第4周,血清DAO水平显著升高,ALB水平呈升高趋势,而CRP、TNF-α、IL-1β、IL-6水平显著下降,并与血清DAO水平的变化呈负相关。结论:肠内营养能够提高CD病人血清DAO活性,并改善病人的营养状况。Objective：To investigate the effect of enteral nutrition （EN） on the plasma diamine oxidase （DAO） activities in active Crohn＇s disease（CD）. Methods：38 patients with active CD were enrolled to be treated with total EN support for 4 weeks. Plasma DAO, albumin , C-reactive protein, TNF-α, IL-1 β and IL-6 were measured at baseline and every 2 weeks. Normal plasma DAO levels were determined by the sera from 53 healthy volunteers. Results： At baseline, plasma DAO values showed to be significantly lower in all patients with CD compared with the healthy subjects. Plasma levels of DAO and albumin were inceased after 4 weeks. By contrast, plasma levels of CRP, TNF-α, IL-1 β and IL-6 were decreased and negatively correlated to levels of DAO. Conclusion： EN can increase plasma levels of DAO by down-regulating immune response, reducing intesitinal inflammation and improving nutritional status of active CD.

关 键 词：肠内营养 克罗恩病 二胺氧化酶 

分 类 号：R459.3[医药卫生—治疗学]