芪参降脂饮抗动脉粥样硬化机制的实验研究  

Mechanism of action of Qishenjiangzhiyin(QSJZY) on experimental atherosclerosis rats

作　　者：贾爱明[1] 张红[1] 

机构地区：[1]大连医科大学第二临床学院中医科,辽宁大连116027

出　　处：《大连医科大学学报》2007年第1期22-23,共2页Journal of Dalian Medical University

基　　金：辽宁省教育厅科学研究计划资助(202203250)

摘　　要：[目的]探讨芪参降脂饮抗动脉粥样硬化(atherosclerosis,AS)的作用机制。[方法]40只大鼠随机分为4组,正常对照组、高脂对照组、不同浓度芪参降脂饮组2组。通过测血脂谱、血FPG、FINS,并计算胰岛素敏感指数(in-sulin sensitivity index,ISI),分析芪参降脂饮降低血脂,改善胰岛素抵抗(insulin resistance,IR)进而起到抗AS的作用。[结果]芪参降脂饮大剂量治疗组大鼠TC(3.36±0.28)mmol/L、LDL-C(1.24±0.31)mmol/L、FPG(8.65±0.78)mmol/L、FINS(12.01±1.09)mmol/L显著低于高脂对照组,而HDL-C(0.97±0.41)mmol/L、ISI(-4.53±0.08)明显升高(P<0.01)。小剂量治疗组与高脂对照组比较无明显差异(P>0.05)。[结论]芪参降脂饮可以降低血脂,改善胰岛素抵抗,进而起到抗AS的作用,且治疗效果与剂量有关。[ Objective] To study the mechanism of action of Qishenjiangzhiyin（QSJZY） on experimental atherosclerosis（AS） rats induced by high fat diet. [ Methods ] Forty rats were randomized into four groups ： normal control group, high - fat model group , two different dose Qishenjiangzhiyin （QSJZY） groups. Serum lipids, FPG, FINS, were measured and ISI was calculated after experiment. The mechanisms of QSJZY＇ s antiatherosclerosis action were deduced. [ Results ] In high dose treatment group, TC （3.36 ± 0. 28 ） mmol/L,LDL - C （ 1.24± 0. 31 ） mmol/L,FPG（ 8.65 ±0. 78 ） mmol/L and FINS （ 12. 01± 1.09 ） mmol/L were significantly lower while HDL- C（0. 97 ±0. 41 ）mmol/L, ISI （ -4.53±0. 08 ） were significantly higher than those in high -fat model group （P 〈 0. 01 ）. No significant difference existed between low dose treatment group and high - fat model group. [ Conclusion ] QSJZY can decrease serum lipids and enhance IS and weaken IR, which might be the mechanisms of QSJZY＇s antiatherosclerosis action . And QSJZY＇s treatment effect is correlated to it＇s dose.

关 键 词：芪参降脂饮 动脉粥样硬化 胰岛素抵抗 

分 类 号：R285.5[医药卫生—中药学]