静息心率增高对老年高血压患者靶器官损害的影响  

Impact of the increase of the resting heart rate on the target organ damage in senile patients with hypertension

作　　者：周哲慧[1] 胡颖[1] 宋雅君[1] 刘沁[1] 李藜[1] 

机构地区：[1]上海市黄浦区中心医院内科,上海200002

出　　处：《临床心血管病杂志》2007年第1期30-32,共3页Journal of Clinical Cardiology

摘　　要：目的：探讨老年高血压患者静息心率（RHR）与靶器官损害的关系及其临床意义。方法：150例老年高血压患者，按RHR水平分为：〈65次／min组（A组），52例；≥65～〈80次／min组（B组），51例；≥80次／min组（C组），47例。对入选患者分别行超声心动图、颈动脉超声及头颅CT或MRI检查，测定RHR、血压、血糖、血脂、体质指数、肌酐、尿素氮、尿酸，进行分组研究。结果：随着RHR水平的增加，收缩压、舒张压、脉压、体质指数、总胆固醇、低密度脂蛋白胆固醇、空腹血糖、尿酸有上升趋势；颈动脉内膜厚度、左室肥厚病例数增加；左室重量指数、临床神经功能缺损程度升高，左室射血分数、日常生活能力下降。各组间比较差异有统计学意义（P〈0．05或P〈0．01）。结论：老年高血压患者随RHR的增高，发生心脑血管损害的机会也在增加，RHR可能是心脑血管疾病发生的危险因素及预后的预测因子。Objective：To investigate the relationship between the resting heart rate （RHR） and the target organ damage in senile patients with hypertension and its clinical significance. Method： According to the level of RHR, 150 senile patients with hypertension were divided into three groups： A group（n= 52 ）, RHR〈65 beats per minute; B group（n=51 ）, 65≤RHR〈80 beats per minute and C group （n=47）, RHR ≥80 beats per minute. Result：Differences with statistical significance （ P〈0. 05 or P 〈0. 01） were found in comparisons of each measured index among three groups. When RHR increased, ①systolic blood pressure, diastolic blood pressure, pulse pressure, body mass index, total cholesterol, low density lipoprotein, blood-fasting sugar and acidum uricum increased;②the number of the cases of thickness of endomembrane of arteria carotis and left ventricular hypertrophy increased③left ventricular mass index and the level of clinical neurologic impairment increased;④left ventricular ejection fraction and activity of daily living decreased. Conclusion： Along with the increase of RHR in senile patients with hypentension, the chance to induce cardio/cerebrovascular diseaces increases. RHR might be the risk factor of cardio-/cerebrovascular diseases and an important prognostic predictor.

关 键 词：高血压 心率 心脑血管疾病 

分 类 号：R544.1[医药卫生—心血管疾病]