常压模拟高住低练对红细胞相关指标和促红细胞生成素、低氧诱导因子-1mRNA表达影响的研究与进展  

Advancement and research on the effect of simulated living high-training low on the related indexes of red blood cells and the expression of erythropoietin and hypoxia inducible factor-1 mRNA

作　　者：林喜秀[1] 瞿树林[1] 

机构地区：[1]湖南师范大学体育学院(运动人体科学专业),湖南省长沙市410012

出　　处：《中国组织工程研究与临床康复》2007年第7期1356-1360,共5页Journal of Clinical Rehabilitative Tissue Engineering Research

基　　金：湖南省自然科学基金(05JJ30066)~~

摘　　要：目的:常压模拟高住低练训练法是近年来提出来的一种新型的高原训练方法,可以解决传统高原训练中存在的不足。就高住低练训练法对红细胞相关指标和促红细胞生成素、低氧诱导因子-1基因表达的影响作一综述,旨在促进高住低练训练法在中国的发展和应用,使其更好地为运动员竞技水平的提高服务。资料来源:应用计算机检索PubMed1972-01/2005-12的相关文章,同时根据相关的参考文献检索了部分文章,检索词“simulated living high-training low training(HiLo),indices of red blood cell,effect;erythropoietin(EPO)、Hypoxia inducible factor-1(HIF-I),Gene”限定语言种类为English,同时计算机检索http://cnki.hunnu.edu.cn1996/2006的相关文章,限定文章种类为中文,检索词“:高住低练,红细胞相关指标,影响,促红细胞生成素,低氧诱导因子,基因。”资料选择:对资料进行初审,选取实验包括常压模拟高住低练运动模型中关于红细胞相关指标和促红细胞生成素基因、低氧诱导因子-1基因表达的影响方面的文献,查找相关文献的全文,判断是否确实是相关研究。纳入条件:①随机对照实验研究。②实验包括对照组与干预组。排除条件:①综述文献。②重复的同一研究。资料提炼:共查找到90篇相关研究文章,38篇符合纳入标准。排除的52篇系为同一研究和综述文献。资料综合:Levine在高住低练训练法的试验发现:高住低练训练组最大摄氧量平均增加了5%,红细胞平均增加了9%,运动能力得到改善,而对照组无论是最大摄氧量、红细胞、还是运动能力均无显著性变化。②高住低练训练法能促使低氧诱导因子-1的产生而对促红细胞生成素的调控,使促红细胞生成素的产生和血红素浓度的变化,促红细胞生成素增加引起红细胞量和Hb浓度的增加;血红素浓度增加可以提高血液运输氧的能力和组织氧化能力。居住在适宜高度(大于20OBJECTIVE： As a new method of altitude training, stimulated living high-training low training （HiLo）, can solve the problems in traditional altitude training. In this paper, we review the effect of simulated living high-training low on the related indexes of red blood cells and the expression of erythropoietin and hypoxia inducible factor-lmRNA to improve the development and application of HiLo, and make it better service for our athletes. DATA SOURCES： A computer-based online search of PubMed was undertaken for the articles published between January 1972 and December 2005, among which partial articles were retrieved according to relevant references with the key words of ＂simulated living high-training low training （HiLo）, indices of red blood cell, effect; erythropoietin, hypoxia inducible factor-1; gene＂. Meanwhile, we searched http：//cnki.hunnu.edu.cn for the relevant articles published between 1996 and 2006 with the same key words in Chinese. STUDY SELECTION： The articles that involved the effect on the indices of red blood cell and the expression of erythropoietin and hypoxia inducible factor-1 mRNA in the model of stimulated living high-training low training through the first trial sport were chosen after the first selection. Then, the full texts of these articles were looked up to identify whether they were the relevant studies. Inclusive criteria： （1）randomised controlled experiments; （2）the experiment including control and intervention groups. Exclusive criteria： （1）review articles; （2）repetitive studies. DATA EXTRACTION： Totally 90 relevant articles were collected, of which 38 were accordant with the inclusive criteria and the 52 repetitive studies or review articles were excluded. DATA SYNTHESIS： （1）Levine discovered that in HiLo the maximal 02 consumption （VO2max） in the training group was increased 5% in the mean and red cell 9% and the ability of exercise was largely improved, while the results of the control group had no significant changes. （2�

关 键 词：体育和训练 红细胞计数 红细胞生成素 DNA结合蛋白质类 基因 

分 类 号：R339.4[医药卫生—人体生理学]