嗅鞘细胞移植结合针灸康复疗法治疗脊髓损伤1例报告  

A case report of spinal cord injury treated by olfactory ensheathing cells transplantation plus acupuncture rehabilitative therapy

作　　者：罗春燕 黄红云 陈琳[1,2] 

机构地区：[1]北京市石景山区西山神经再生和功能重建研究所,北京市100041 [2]北京市西山医院暨北京康复中心神经外科,北京市100041

出　　处：《中国组织工程研究与临床康复》2007年第7期1376-1377,共2页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：应用嗅鞘细胞移植结合针灸康复等疗法治疗脊髓损伤患者1例,以“外伤后致双下肢运动障碍21年”入院,根据专科查体及胸椎MRI辅助检查,诊断为缺血性脊髓损伤(T11以下)。以T11脊突为中心作纵切口,长约3cm,选择萎缩脊髓与正常脊髓之间无血管区分别注射嗅鞘细胞0.5×109L-1。止血,缝合,切口包扎固定,给予常规抗生素治疗。术后14d,皮温稍有升高,给予针灸及康复治疗。针灸选穴为:百会,印堂,合谷,中极,关元,髀关,风市,伏兔,犊鼻,足三里,血海,阴陵泉,三阴交,解溪,太溪,复溜,太冲,申脉。平补平泻,留针30min。康复治疗:给予点按穴位,推拿肌肉萎缩肢体部位,蹬自行车,强制站立等康复训练。治疗2周后,患者皮温升高,以右腿升高明显。下肢排汗量减少,体力增强,行走3000m无疲劳感。表明嗅鞘细胞移植后,结合针灸、按摩及各种康复训练,对晚期脊髓损伤神经进一步的症状恢复和改善肌肉萎缩状态有一定意义。To cure one patient with spinal cord injury （SCI）, who hospitalized for both legs couldn＇t moving for 21 years after extemal injury, by using the olfactory ensheathing cells （OECs） transplant and acupuncture treatment. The patient was diagnosed as ischemic SCI （below the T11） according to the neurological test and MRI for dorsal vertebra. T11 spinous process was made to be the center mark through operation with the length of about. 3 cm. The area between the atrophique spinal cord and normal spinal cord without vessel was selected and injected with OECs 0.5×10^9 L^-4. Hemostasis, stitching, binging and fixation ware performed respectively, and normal treatment was given by using antibiotics, At 14 days after operation, the ternperatura on skin increased a little, and acupuncture treatment and rehabilitation therapy were performed. The acupoints ware as following： Baihui （DU21 ）, Y/ntang （EX-HN3）, Hegu （LI4）, Zhongji （RN3）, Guanyuan （RN4）, B/guan （ST31）, Fengshi （GB31）, Futu （ST32）, Dubi （EX-LE5）, Zusanli （ST36）, Xuehai （SP10）, Yinlingquan （SP9）, Sanyinjiao （SP6）, Jiexi （ST41）, Taixi （KI3）, Fuliu （KI7）, Taichong （LR3）, and Shenmai （BL62）. The treatment was given by mild reinforcing and attenuating with 30-minute retention. The rehabilitation： The needle pressing, manipulation for muscular atrophy, bicycle practicing, andimperative standing were performed. After 2 weeks, the skin temperature of the patient increased with obvious improvement in his right leg. The physical strength of the patient was reinforced with less perspiration, and the patient could walk 3 km without fatigue, which indicated that after OECs transplant, treatment with acupuncture, massage and other rehabilitation trainings could facilitated the improvement of SCI of the advance stage as wall as the amelioration of muscular atrophy.

关 键 词：细胞移植 嗅神经 针灸疗法 脊髓损伤 

分 类 号：R651.2[医药卫生—外科学]