紫外分光光度法测定法罗培南钠片的溶出度  

Study on dissolution of faropenem sodium tablets by UV spectrophotometry

作　　者：汤洁[1] 

机构地区：[1]安徽医科大学第一附属医院药剂科,安徽合肥230022

出　　处：《安徽医药》2007年第2期125-126,共2页Anhui Medical and Pharmaceutical Journal

摘　　要：目的建立法罗培南钠片的溶出度考察方法，以有效控制药品质量。方法以水1000ml为溶出介质，转速为75r·min^-1，30min时取样，在306am波长处测其吸收度计算溶出量。结果法罗培南钠在浓度为4．27～42．66mg·L^-1吸收度与浓度呈良好线性关系，Y=0．0180X-0．O004，相关系数r=0．9999，平均加样回收率为99．8％，RSD=0．80％，3批样品的30min溶出度均在90％以上。结论方法简便、准确，结果可靠。可用于法罗培南钠片的溶出度测定。Aim To determine the dissolution of faropenem sodium tablets. Methods The dissolution was calculated according to Chinese Pharmacopeia（ 2005 ） with water as the solvent. UV spectrophotometry was used, and the detection wavelength was 306 nm. Results The method showed a good linear relationship in the range of 4.27 - 42.66 mg ~ L- 1 （ r = 0. 9999 ）. The average recovery was 99. 8% ,and RSD was 0.80%. The dissolutions of 3 batches of samples were all above 90%. Conclusion The method is simple, accurate, and can be used as the quality control method for determing the dissolution of faropenem sodium tablets.

关 键 词：法罗培南钠片 溶出度 紫外分光光度法 

分 类 号：R927[医药卫生—药学]