胎儿期铅暴露水平与脐带血钙、铁、锌含量的相关研究  

Relationship between prenatal lead exposure and umbilical blood calcium,iron,zine.

作　　者：李生慧[1] 付葵[2] 

机构地区：[1]上海交通大学医学院附属新华医院上海儿科医学研究所上海市环境与儿童健康重点实验室,上海200092 [2]山西省妇幼保健院,山西太原030013

出　　处：《中国儿童保健杂志》2007年第1期9-10,共2页Chinese Journal of Child Health Care

基　　金：上海市儿科学重点学科(T0204);上海市医学重点学科(05Ⅲ002)资助项目

摘　　要：【目的】研究胎儿期铅暴露水平与胎儿体内钙、铁、锌等矿物元素含量的相关关系。【方法】以脐血血铅含量作为胎儿期铅暴露的指标,脐血钙、铁、锌含量作为胎儿体内相应元素含量的指标,采用BUCK-210型原子吸收光谱仪石磨炉原子吸收光谱法和分光光度法检测100份脐带血标本四种元素的含量。【结果】胎儿体内血铅水平处于在CDC标准的Ⅰ级(<0.483μmol/L)、Ⅱ-A(0.483-0.676μmol/L)水平时,即与二价元素钙、铁含量呈显著负相关(P<0.05);血铅≥0.247μmol/L者,其脐血钙、铁含量明显低于血铅水平<0.247μmol/L者,差异有显著性(P<0.05)。【结论】在认为相对安全的铅暴露水平,随着胎儿体内血铅水平的上升,二价元素钙、铁含量有下降趋势,亦即铅作为一种外来毒素,有可能干扰胎儿体内的正常矿物元素代谢。[Objective] To survey the relationship between prenatal lead exposure and umbilical blood calcium,iron, zine. [Methods] Umbilical blood lead levels （CBPb）, as an indicator for intrauterine exposure to lead, and umbilical blood calcium （CBCa）, iron（CBFe）, zinc （CBZn） levels, as marker of fetus calcium,iron,zinc content respectively, were investigated in 100 infants. [Results] At the investigated exposure level （CBPb= 0. 132～0. 579 μmol/L）, CBCa and CBFe were adversely affected （P〈0.05）. CBCa .CBFe with CBPb above and equal to 0. 247 /＊mol/L tended to be significantly lower compared with those CBPb below 0. 247 μmol/L（P〈0.05）. [Conclusion] Lead exposure at safe level tra- ditionally cnuld adversely affected the fetus elements metabolism.

关 键 词：铅 脐血 钙 铁 锌 

分 类 号：R722[医药卫生—儿科]