左卡尼汀治疗微血管性心绞痛疗效观察  

Effect of L-carnitine on Patients with Microvascular Angina

作　　者：李跃艳[1] 全智华[1] 谭小进[1] 阳志成[2] 

机构地区：[1]南华大学附属第一医院心血管内科,湖南衡阳市421001 [2]南华大学生物化学与分子生物学教研室

出　　处：《中国康复理论与实践》2007年第2期171-172,共2页Chinese Journal of Rehabilitation Theory and Practice

摘　　要：目的观察左卡尼汀治疗微血管性心绞痛的临床疗效。方法48例微血管性心绞痛患者随机分为试验组和对照组,各24例,试验组采用左卡尼汀静滴,对照组口服单硝酸异山梨醇,用药时间均为12周。结果两组患者的心绞痛发作次数、硝酸甘油用量明显减少(P<0.01),运动至出现ST段压低1mm时间、运动至出现心绞痛时间、运动持续时间延长(P<0.05),运动诱发ST段缺血型下移之和(∑ST)减小(P<0.05),试验组患者的总胆固醇、甘油三酯和低密度脂蛋白胆固醇分别降低20.3%、32.7%和16.6%,高密度脂蛋白胆固醇升高34.5%(P<0.01)。结论左卡尼汀治疗微血管性心绞痛疗效肯定,与硝酸酯类药相似。Objective To observe the therapeutic efficacy of L-carnitine on patients with microvascular angina （MVA）. Methods 48 MVA patients were divided randomly into the trail group and control group with 24 cases in each group. The patients of the trail group were treated with L-carnitine vein dropping, those of the control group took isosorbide-mononitrate orally. All treatment lasted for 12 weeks. Results After the treatment, attack times of MVA and consumption of nitroglycerin of the patients in two groups decreased obviously （ P〈0.01）. The time for inducing angina, the time for 0.1 mV ST segment depression, the total exercise time and ∑ST depression by exercise were improved obviously （P〈0.05）. The serum total cholesterol, triglyceride and low density lipoprotein cholesterol decreased by 20.3 %, 32.7 %and 16.6% respectively, and high density lipoprotein cholesterol levels increased by 34.5 % in the trail group （P 〈0.01）. Conclusion L-carnitine has affirmative effect on MVA, same as isosorbide-mononitrate.

关 键 词：左卡尼汀 微血管性心绞痛 心肌缺血 运动耐量 

分 类 号：R541.4[医药卫生—心血管疾病]