聚精丸对弱精子症患者精浆一氧化氮、超氧化物歧化酶的作用机制研究  

Effects of Jujingwan on Nitric Oxide and Superoxide Dismutase in Seminal Plasma of Asthenospermia Patients

作　　者：金保方[1] 杨晓玉[2] 卞廷松 周翔[4] 黄宇烽[1] 王修来[5] 周作民 徐福松[2] 

机构地区：[1]南京军区南京总医院解放军临床检验医学研究所生殖遗传研究室,江苏南京210002 [2]南京中医药大学男科学教研室,江苏南京210029 [3]常州市中医院男科,江苏常州213003 [4]江苏省中西医结合医院男科,江苏南京210028 [5]南京军区南京总医院博士后科研工作站,江苏南京210002 [6]江苏省生殖医学重点实验室,江苏南京210029

出　　处：《中华男科学杂志》2007年第1期87-90,共4页National Journal of Andrology

基　　金：江苏省政府"六大人才高峰"资助项目(2005A5)

摘　　要：目的:研究聚精丸治疗弱精子症的可能机制,为寻找其作用机制提供新的线索。方法:选择弱精子症患者34例,给予聚精丸治疗3个月,治疗前后分别作精液常规及精浆一氧化氮(NO)含量和超氧化物歧化酶(SOD)活性测定,观察治疗前后精液常规参数以及NO含量、SOD活性的变化。结果:与治疗前相比,治疗后精液常规参数均有显著性改变(P<0.05或P<0.01);精浆NO值无明显变化(P>0.05);而SOD活性由(95.97±20.75)μg/L下降为(76.14±19.99)μg/L(P<0.05)。弱精子症治疗前精浆NO含量和SOD活性之间呈负相关(r=-0.246,P<0.05)。结论:聚精丸可以显著改善弱精子症患者精子活动率,但聚精丸的良好疗效可能并不体现在精浆NO含量和SOD活性值的改变。Objective： To explore the possible action mechanism of Jujingwan on asthenospermia. Methods： Semen routine analyses and determination of nitric oxide （NO） concentration and superoxide dismutase （SOD） activity in seminal plasma were performed in 34 cases of asthenospermia. The changes of NO concentration and SOD activity before and after the treatment with Jujingwan were observed. Results： Compared with pre-treatment, there was no significant change in NO concentration, and the activity of SOD decreased significantly after the treatment （ [ 95.97 ±20.75 ] μg/L vs [ 6.14 ± 19.99 ] μg/L）. There was negative correlation between NO concentration and SOD activity before the treatment （ r = - 0.246, P 〈 0.05 ）. Conclusion： Jujingwan can significantly improve sperm viability in patients with asthenospermia. However, the excellent effects of Jujingwan are not displayed in the changes of NO concentration and SOD activity.

关 键 词：聚精丸 弱精子症 精子活动率 一氧化氮 超氧化物歧化酶 

分 类 号：R256.5[医药卫生—中医内科学]