儿童脑膜瘤的特点与治疗（附12例报告及文献复习）  

Characteristics and treatment of meningiomas in children-reports of 12 cases and literature review

作　　者：刘玉光[1] 李峰[1] 朱树干[1] 刘猛[1] 吴承远[1] 

机构地区：[1]山东大学齐鲁医院神经外科,250012

出　　处：《中华神经外科杂志》2007年第1期14-16,共3页Chinese Journal of Neurosurgery

摘　　要：目的研究儿童脑膜瘤的特点与治疗。方法对12例儿童脑膜瘤结合文献进行了回顾性分析。结果12例中，男女之比为2：1；年龄1．5～15岁，平均11．5岁；颅内压增高是最常见的临床表现；大脑凸面5例，脑室内2例，矢状窦旁2例，大脑镰旁、枕骨大孑L及脑实质内各1例；肿瘤最大径2—8em；12例全部行手术肿瘤全切除。病理诊断分别为内皮型2例、纤维型3例、混合型5例、血管瘤型和沙粒型各1例。术后无死亡，除1例术后脑积水行脑室腹腔分流术外，其他病例无术后并发症。经6—15年（平均6．5年）随访无肿瘤复发。结论与成人相比，儿童脑膜瘤男性多于女性；癫痫发生率低；常合并多发性神经纤维瘤病；发生在脑室内和幕下的比例比较高，而矢状窦旁和大脑镰旁的发生率较低；钙化、囊性变和肿瘤出血发生率高。手术全切除是治疗儿童脑膜瘤的首选方法。Objective To study the characteristics and treatments of meningiomas in children. Methods 12 cases of meningiomas in children treated in Qilu hospital were analyzed retrospectively and the literature was reviewed. Results In this series of 12 cases, the ratio of boys and girls was 2： 1, the age ranged from 1.5 to 15 years （mean 11.5 years）. Increased intracranial pressure was the most common symptoms and signs. The tumors were located in the convexity in 5, ventricles in 2, parasagittal, parafalcine and intraparenchymal regions in 1 respectively. The diameters of tumours ranged from 2 to 8 cm. Complete tumor excision was achieved in 12 cases. The pathological subtypes of meningiomas was endothelid in 2, fibroblastic in 3, mixed in 5, angiomatous and psammomatous in 1 respectively. In this series, postoperatively, no death and complications occurred except one case had hydrocephalus, whom the ventriculoperitoneal shunt was performed. No tumour recurred after a 6- to 15-year （ mean 6.5 years） followup. Conclusions Compared with the meningiomas in adult, meningiomas in children occur predominantly in male with lower incidence of epilepsy, and are frequently associated with multiple neurofibromatosis. The most common locations are intraventricular and infratentorial regions, while fewer tumors arise from the parasagittal region or the falx. In addition, calcification, cystic degeneration and intratumoural hemorrhage are also more common in children. Total excision is the first choice to treat the meningiomas in children.

关 键 词：儿童 脑膜瘤 临床特点 治疗 预后 

分 类 号：R686[医药卫生—骨科学]