中枢神经细胞瘤的诊断和治疗  

The diagnosis and treatment of central neurocytonm

作　　者：林欣[1] 周定标[1] 张远征[1] 桂秋萍[2] 余新光[1] 许百男[1] 张纪[1] 段国升[1] 

机构地区：[1]解放军总医院神经外科,100853 [2]解放军总医院病理科,100853

出　　处：《中华神经外科杂志》2007年第1期24-27,共4页Chinese Journal of Neurosurgery

摘　　要：目的深入认识中枢神经细胞瘤，以期提高本病的诊疗水平。方法回顾性总结我科22例中枢神经细胞瘤的临床表现、影像学检查、诊断及治疗效果。结果所有22例均手术治疗，术后11例全切除病例中4例联合放射治疗，8例次全切除病例中3例联合放射治疗、1例化疗，3例部分切除病例中1例联合放射治疗、1例化疗。死亡7例，失访6例，其余9例随访2个月至35年，均未见肿瘤复发或再长。结论脑室内中枢神经细胞瘤手术风险较大，死亡率较高；运用显微神经外科及术中导航技术切除肿瘤可有效降低致残率和死亡率；联合术后放疗可减少本病复发；化疗的疗效有待评价。Objective To recognize the central neurocytoma in detail, so as to improve its diagnostic level and attain better prognosis. Methods A retrospective review of 22 cases of operated central neurocytoma was performed, including their clinical manifestations, imaging examinations, diagnostic modalities and surgical outcomes. Results All 22 patients received the operation firstly, while 7 of them died postoperatively. Total removal of tumors was achieved in 11 cases, and 4 of them received the combined radiotherapy postoperatively. Subtotal removal was achieved in 8 cases, 4 of them received adjuvant radiotherapy or chemotherapy. Partial removal was achieved in 3 cases, 2 of them received radiotherapy or chemotherapy. During follow-up ranging is from 2 months to 35 years, 9 cases adjuvant got satisfiying prognosis and 6 cases were lost. Conclusion The risk and mortality of operation of central neurocytoma are high. Using the microneurosurgical technique and intraoperative neuronavigation system will be helpful to reduce the mortality. The combination of postoperative radiotherapy is good to control the recurrence, while the use of chemotherapy still waits for evaluation.

关 键 词：中枢神经细胞瘤 诊断 治疗 

分 类 号：R686[医药卫生—骨科学]