腺苷脱氨酶在慢性病毒性肝病中的诊断价值研究  

The clinical value of adenosine deaminase for diagnose of chronic viral hepatitis

作　　者：杨彦改 马士恒[2] 李福建[1] 石鹏辉[1] 马晓红[1] 田桂荣[1] 刘文珍[1] 

机构地区：[1]保定市传染病医院,河北保定071000 [2]河北大学附属医院,河北保定071000

出　　处：《临床肝胆病杂志》2007年第1期17-18,共2页Journal of Clinical Hepatology

摘　　要：探讨腺苷脱氨酶(ADA)在慢性病毒性肝脏疾病中的诊断价值。应用全自动生化分析仪检测ADA及各项肝功能指标,放射免疫法检测肝纤维化指标。从慢性HBV携带者、慢性肝炎轻度、慢性肝炎重度至肝硬化,血清ADA逐渐升高。血清ADA与血清门冬氨酸转氨酶、球蛋白、门静脉宽度、脾脏厚度、Ⅲ型前胶原呈显著正相关,与白蛋白、胆碱脂酶呈显著负相关。慢性肝病患者中血清ADA升高提示病情不断进展,可反映肝脏储备合成功能逐渐降低,也可提示体内有活动性肝纤维化。To study the clinical value of adenosine deaminase for diagnose of chronic viral hepatitis. The adenosine deaminase and liver function indexes of patients were determined by OLYMPUS AU400. The fibrosis indexes were detected by BIA assay. The serum adenosine deaminase in the patients with liver diseases, from HBV carriers, mild chronic hepatitis, severe chronic hepatitis to liver cirrhosis, increased gradually. The serum adenosine deaminase was correlated positively with serum aspirate aminotransferase, globulin, the width of portal vein, the thiekniss of spleen and type Ⅲ procollagen. It was correlated negatively with serum albumin and cholinesterase. The higher serum adenosine deaminase expressed, was the worse illness showed in chronic viral hepatitis patients. It could reflect the decrease of liver synthesization function and active liver fibrosis.

关 键 词：慢性肝炎 肝硬化 腺苷脱氨酶 肝功能 Ⅲ型前胶原 

分 类 号：R512.6[医药卫生—内科学]