充血性心力衰竭患者血浆脑钠素水平与其心功能关系的研究  

Research of relation between brain natriuretic peptide and cardiac function in patients with congestive heart failure

作　　者：李敏 朱静 王祥[2] 

机构地区：[1]湖北省武汉市新洲区人民医院心内科,湖北武汉430400 [2]湖北省武汉市协和医院心内科

出　　处：《心血管康复医学杂志》2007年第1期30-32,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨充血性心力衰竭患者(CHF)血浆中脑钠素(BNP)水平与心力衰竭严重程度、心功能状况的关系。方法:研究对象分为心衰组(87例)和心功能正常对照组(30例),采用酶联免疫吸附法(ELISA)法测定87例心衰患者,30例对照组BNP水平,心衰组待心功能纠正后再次检测。结果:心衰组病人血浆BNP水平与对照组相比有显著性差异(P<0.01),随着心功能纽约分级程度的加重而显著增加(P<0.05),并随着心功能的恢复而BNP水平下降(P<0.01),与对照组无显著差异(P>0.05)。结论:脑钠素水平可较好的反映心功能,可作为诊断心力衰竭及评估心功能的生化指标之一。Objective： To explore the relation between brain natriuretic peptide （BNP） and cardiac function in patients with congestive heart failure （CHF）. Methods： The study subjects were divided into two groups： CHF group and normal heart function group （control group）. The BNP was detected by ELISA. When cardiac function of CHF group was corrected the BNP was detected again. Results： BNP level of CHF group was higher than that of control group （P〈0.01）, and declined with cardiac function improvement （P〈0.05）. Conclusion： BNP level has a relation with cardiac function and it may be a good biomarker in diagnosing CHF and evaluating cardiac function.

关 键 词：心力衰竭.充血性 脑钠素 心室功能 

分 类 号：R259.416.1[医药卫生—中西医结合]