替米沙坦对老年高血压病患者脉压的影响  

Effects of telmisartan on pulse pressure in aged patient with hypertension

作　　者：覃天锦[1] 王际军[1] 阎婷[1] 

机构地区：[1]济南市第三人民医院心内科,山东济南250101

出　　处：《心血管康复医学杂志》2007年第1期63-65,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:探讨血管紧张素Ⅱ的Ⅰ型受体拮抗剂(ARB1)替米沙坦对老年高血压病患者脉压的影响。方法:符合WHO/ISH高血压病诊断标准的高血压病Ⅰ、Ⅱ级患者90例,治疗组56例,口服替米沙坦40～80mg,1次/d;对照组34例,口服赖诺普利5～10mg,1次/d。结果:用药半年后替米沙坦组,赖诺普利组收缩压(SBP)、舒张压(DBP)均显著下降(P分别<0.001,<0.01)、替米沙坦组脉压(PP)亦有明显缩小(P<0.01)。结论:替米沙坦不仅是安全可靠的降压药,而且还可以缩小脉压,具有器官保护作用,可作为老年高血压一线用药。Objective： To evaluate the effects of telmisartan on pulse pressure in aged patient with hypertension. Methotis： A total of 90 cases with hypertensive disease were definitely diagnosed according to WHO criterion. In 56 cases were administered telmisartan orally 40～80mg per day for six months; lisinopril treatment of 34 cases used as control. Results： After six months in telmisartan group and lisinopril group the SBP, DBP all decreased significantly, P 〈 0.001, 〈0.01 respectively; PP significantly decreased （P〈0.01） in telmisartan group. Conclusion： Telmisartan is not only safe and effective in treating hypertension but also decreases pulse pressure. It can protect cardio-cerebro-renal function and be used as an antihypertensive drug in first consideration.

关 键 词：替米沙坦 赖诺普利 高血压 

分 类 号：R544.1[医药卫生—心血管疾病]