静脉注射美托洛尔、地尔硫卓治疗快速心房纤颤的临床疗效观察  

Therapeutic efficacy of intravenous metoprolol and diltiazem in patients with rapid atrial fibrillation

作　　者：林斌[1] 章耀[1] 戴海岳[1] 

机构地区：[1]温州市第二人民医院心内科,浙江温州325000

出　　处：《心血管康复医学杂志》2007年第1期69-71,共3页Chinese Journal of Cardiovascular Rehabilitation Medicine

摘　　要：目的:观察美托洛尔注射液和地尔硫卓注射液治疗快速房颤的有效性和安全性。方法:105例符合入选标准的快速房颤患者被随机分为3组,美托洛尔组39例:5mg美托洛尔缓慢静脉注射,观察5min,如无效重复一次,连续用药3次,总量15mg;地尔硫卓35例:地尔硫卓15mg稀释后静脉注射,观察15min,如无效重复1次,继以15mg/h维持。西地兰组31例:西地兰0.2～0.4mg稀释后静脉注射,观察10min,如无效追加0.2～0.4mg,连续用药3次;总量0.6～1.0mg。记录用药前、后心室率和血压变化,并比较在各观察时间点上的有效率。结果:与西地兰相比,美托洛尔和地尔硫卓起效更快[(36.9±11.6)min∶(8.2±4.5)min∶(9.1±3.8)min,P<0.05],心室率下降幅度更明显(25.22%∶33.32%∶37.50%,P<0.05),治疗有效率更高(71.0%∶89.7%∶91.4%,P<0.05)。而美托洛尔组和地尔硫卓组之间无显著性差异。三组均无严重不良反应发生。结论:美托洛尔注射液和地尔硫卓注射液均能快速、安全、有效控制快速房颤的心室率。Objective： To observe the efficacy and safety of intravenous metoprolol and dihiazem for control of ventricular rate in patients with atrial fibrillation. Methods： A total of 105 patients with atrial fibrillation were randomized to 3 groups： metoprolol group （n=39）： treated with injected metoprolol. Diltiazem group （n=35）： treated dehiazem injected; Cedilanid group （n=31）： treated with cedilanid injected. Electrocardiogram and blood pressure recordings were performed before and after drug administration. The efficiencies at different time points were compared. Results： Compared with the cedilanid group, metoprolol and diltiazem took faster effect [（36.9±11.6） min ： （8.2±4.5） min ： （9.1±3.8） min, P〈0.05], the ventricular rate mort decreased （P〈0.05）, and had a higher total effective rate （71.0%： 89.7%： 91.4%, P〈0.05） . There was no diversity between metoprolol group and diltiazem group. There was not any severe side effect in three groups. Conclusion： To control ventricular rate of rapid atrial fibrillation by intravenous metoprolol and diltiazem is rapid, safe and efficacious.

关 键 词：心房颤动 美托洛尔 地尔硫卓 治疗效果 

分 类 号：R541.75[医药卫生—心血管疾病]