响应曲面法建立超临界CO_2萃取结晶穿心莲内酯工艺模型  

Technology model with response surface methodology for supercritical CO_2 extraction and crystallization of andrographolide

作　　者：张文成[1] 谢慧明[1] 张兴元[2] 潘见[1] 

机构地区：[1]合肥工业大学农产品生物化工教育部工程研究中心,合肥230009 [2]中国科学技术大学高分子科学与工程系,合肥230026

出　　处：《农业工程学报》2007年第1期223-228,共6页Transactions of the Chinese Society of Agricultural Engineering

基　　金：教育部科技创新工程重大项目培育基金项目(704027);国家自然科学基金资助项目(29976008)

摘　　要：以穿心莲内酯含量为30%的穿心莲浸膏为试验原料,采用响应曲面分析法(R esponse SurfaceM ethodo logy,RSM)建立了超临界CO2萃取结晶穿心莲内酯结晶率的二次多项数学模型,验证了数学模型的有效性,并探讨了萃取结晶压力、温度、时间对结晶率的作用规律。根据该模型进行了工艺参数的优选,以结晶率为指标,试验所得穿心莲内酯超临界CO2萃取结晶优化工艺条件为:压力20.88 M Pa,温度50.27℃,时间97.02 m in,该条件下结晶率高达74.77%。The extract of Andrographis paniculata（Burm, f. ） Nees （30% andrographolide） was used as experimental material, and the model of a second order quadratic equation for supercritical carbon dioxide extracting and crystallizing andrographolide was built by response surface methodology（RSM）. The adequacy of the model equation for predicting the optimum response values was verified effectively by the validation. Effects of pressure, temperature and time on crystallization ratio were investigated. The optimized technology parameters were pressure of 20. 88 MPa, temperature of 50. 27℃, time of 97.02 min, and under these conditions the crystallization ratio of andrographolide was up to 74.77%.

关 键 词：超临界CO2 萃取结晶 穿心莲内酯 响应曲面分析法 结晶率 工艺模型 

分 类 号：TQ028[化学工程]