妊娠合并梅毒80例临床分析  

Syphilis in pregnancy women

作　　者：赖永珲[1] 杨帆[1] 洪福昌[1] 王立阳[1] 阎冬冬[1] 林丽君[1] 

机构地区：[1]深圳市慢性病防治院皮肤性病科,广东省深圳518020

出　　处：《中国基层医药》2007年第1期49-50,共2页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨妊娠合并梅毒的临床分期特点及妊娠结局。方法将80例经血清学检查确诊为梅毒的孕妇分为两组：治疗组40例，行全疗程抗梅毒治疗，应用普鲁卡因青霉素80万u肌内注射，每日1次，连续15d；或苄星青霉素240万u肌内注射，每周1次，连续3周。未治疗组40例，未能行全疗程抗梅毒治疗。结果80例妊娠合并梅毒患者中，一期1例（1．3％）、二期3例（3．7％）及潜伏梅毒76例（9S．0％）。治疗组流产、死胎、死产、新生儿死亡均为0，新生儿先天梅毒为7例（17．5％）；未治疗组流产8例、死胎8例、死产2例、新生儿死亡1例，新生儿先天梅毒12例。两组比较，差异有统计学意义（P〈0．05）。结论（1）妊娠合并梅毒患者的临床分期以潜伏梅毒为主，容易误诊。（2）妊娠合并梅毒患者有不良妊娠结局，但在妊娠期行规范并及早的抗梅毒治疗，能很好地控制早产、死胎，明显降低新生儿先天梅毒的发生。Objective To investigate obstetric treatment and pregnancy outcomes of syphilis infection during pregnancy. Methods 80 pregnant women diagnosed with syphilis by serological assays were divided into treated group and untreated group according to whether they accepted full dose treatment against syphilis or not. Patients in the treated group received procaine penicillin（0.8 million units once per day） for 15 days or received an intramuscu- lar injection of henzathine penicillin（2.1 million units once per weeks） for three weeks. The outcome of pregnan after treatment was observed and compared between the two groups. Results There was 1- （1.3%）ease of primary syphilis,3（3.7 % ） eases of second syphilis, and 76（95.0 % ） cases of latent syphilis among the 80 cases. The occurrences of natural hortion,fetal intrauterine death,stillbirth and newborn death were 0 ,and there were 7 cases of congenital syphilis in the treated group;While there were 8,8,2,1, and 12 respectively in the untreated group. Conclusions Pregnant syphilis is prone to be misdiagnosed because of its slight symptom;So it is especially important to screen syphilis as a routine among high risk pregnant. Women premature,fetal death and congenital syphilis can be well controlled through regular and early treatment during pregnancy; Yet congenital syphilis can be avoided completely.

关 键 词：妊娠并发症 感染性 梅毒 妊娠结局 

分 类 号：R7[医药卫生—临床医学]