硫酸乙酰肝素多糖类似物的抗乳腺癌活性研究进展  

Development progresses of heparan sulfate polysaccharide analogs with anti-breast cancer activity

作　　者：谢少凡[1] 柳欣[2] 蒋明[2] 刘长林[1] 刘剑峰[2] 

机构地区：[1]华中科技大学化学系,生命科学与技术学院武汉430074 [2]华中科技大学生命科学与技术学院,武汉430074

出　　处：《中国新药杂志》2007年第1期11-16,共6页Chinese Journal of New Drugs

基　　金：国家自然科学基金资助项目(30270666和30100092);湖北省杰出青年基金(2004ABB005)

摘　　要：硫酸乙酰肝素(heparan sulfate,HS)参与乳腺癌发生和发展的多个环节,随着HS对细胞生长因子调节机制研究的深入,HS多糖类似物的研发已经成为当前研究的热点。现综述HS结构及在乳腺癌发生发展中的作用和机制、HS多糖类似物的分类、天然产物中提取的多糖和化学修饰的多糖衍生物的抗癌活性及构效关系的研究进展。Heparan Sulfate （HS）is involved in many pathological processes of breast cancer.With the deep insights of the mechanism of growth factors modulated by HS, the research and development of heparan sulfate polysaccharide analogs became the hotspot. This paper reviews the role and bioactive mechanism of HS in pathological processes of breast cancer as well as research progresses in the classification, anticancer activity and structure-activity relationships of HS polysaccharides analogs isolated from nature sources and chemosynthesis.

关 键 词：乳腺癌 硫酸乙酰肝素 多糖类似物 抗癌药物 生长因子 

分 类 号：R979.1[医药卫生—药品] R965.1[医药卫生—药学]