QTVI对2型糖尿病患者微量白蛋白尿与左心收缩功能的相关性研究  

The relationship between left ventricular systolic function and albuminuria in type 2 diabetes meuitus patients by quantitative tissue velocity imaging

作　　者：刘芳[1] 张新书[1] 王佑民[2] 郑慧[1] 孔晓春[1] 孙莉[1] 

机构地区：[1]安徽医科大学第一附属医院超声波科,合肥230022 [2]安徽医科大学第一附属医院内分泌科,合肥230022

出　　处：《安徽医科大学学报》2007年第1期73-75,共3页Acta Universitatis Medicinalis Anhui

摘　　要：目的应用定量组织速度成像技术(QTVI)研究2型糖尿病(T2DM)患者微量白蛋白尿与左心收缩功能的相关性。方法60例T2DM患者按尿白蛋白排泄率(UAER)分为2组:正常白蛋白尿(NAU)组、微量白蛋白尿(MAU)组,正常对照组(NC)30例。收集3组研究对象的相关临床资料,应用QTVI获得左室侧壁、后间隔、前壁、下壁、前间隔、后壁二尖瓣环处的收缩期峰值速度(Vs),计算平均Vs(AVs),对这些参数进行组间比较及相关性研究。结果①MAU组空腹血糖(FPG)、餐后2h血糖(PPG)、总胆固醇(TC)高于NC(P<0.01)。②MAU组左室六个室壁Vs、AVs较NC组降低(P<0.01)。③通过线性逐步回归分析可知T2DM患者微量白蛋白尿可以作为二尖瓣环AVs的独立影响因素。结论微量白蛋白尿不仅是2型糖尿病肾病的早期敏感诊断指标之一,同时也是左心收缩功能受损的重要预报指标之一,且是独立影响因素。Objective To evaluate the relationship between Left ventr-icular systolic function and albuminuria in type 2 diabetic patients by quantitative tissue velocity imaging. Methods 60 type 2 diabetic patients and 30 norreal controls（NC） were included. On the basis of urinary albumin excretion rate （UAER）, patients were classified into ： no albumi-nuria （ n = 30 ）, microalbuminuria （ n = 30 ）. The correlated clinical information and the systolic peak velocity（Vs） of 6 mitral annulus sites by QTVI were measured. Results 1. The plasma levels of FPG,PPG ,TC in MAU group were higher than the NC（P 〈0. 01 ）. 2. The Vs and 6 - site average Vs（AVs） in microalbuminuria group were lower than the NC （P 〈 0.01 ）. 3. In multi-variate analysis, albuminuria status remained independently associated with AVs. Conclusion The left ventricular systolic function in type 2 diabetic patients was impaired in microalbuminuria group and microalb-uminuria was independently associated with it.

关 键 词：超声心动描记术 糖尿病 2型/超声检查 白蛋白 尿 心室功能 左 

分 类 号：R331.31[医药卫生—人体生理学] R587.1[医药卫生—基础医学]