HLA体液致敏对肾移植的影响  

Effects of HLA antibodies on graft survival in kidney transplantation

作　　者：萧露露[1] 张升[1] 叶欣[1] 肖巧珍[1] 高伟 郑克立[3] 张仕光[3] 

机构地区：[1]广州器官移植配型中心,510095 [2]第一军医大学附属珠江医院肾脏透析移植中心 [3]中山医科大学第一附属医院器官移植中心

出　　处：《中华器官移植杂志》1996年第3期134-136,共3页Chinese Journal of Organ Transplantation

摘　　要：通过对688例等待肾移植受者的 HLA 体液致敏状态与移植效果的观察,以探讨移植受者高度致敏状态与肾移植效果的关系。研究结果显示,等候移植受者中有26.31%群体反应性同种抗体(PRA)阳性,PRA 阳性受者中仅53.7%的患者补体依赖性淋巴细胞毒(CDC)阴性;PRA≥30%的受者即使接受 CDC 阴性的供体,仍然100%发生超急排斥,90%丧失移植物。说明PRA 峰值表达受者的致敏水平,直接影响移植肾存活。因此,将 PRA 分析列入配型常规,使移植医师术前就能了解移植受者的致敏状态,对预测和预防严重排斥反应以及改善肾移植的效果具有重要意义。Data from 688 cases of kidney transplantation has been analysed to determine the effects of HLA antibodies on graft survival in kidney transplantation.PRA positive rate was 26.31% among the patients waiting for kidney transplantation.All patients with PRA≥30% had hyperacute rejection and 90.0% of these cases lost grafts though they received the kidneys from the donors with negative donor specific crossmatch.The results showed that the PRA value is very useful in predicting rejection and results of kidney transplantation.The PRA should be used as a routine tissue typing program in kidney transplantation.

关 键 词：人白细胞抗原 抗体 超急排斥 肾移植 排斥反应 

分 类 号：R699.2[医药卫生—泌尿科学]