老板口服液的急性及长期毒性研究  

Acute and Chronic Toxicity of Laoban Oral Liquid (A medicine made by the Ants and Rhodiola Sachalinensis A. Bor)

作　　者：符健[1] 王玉芳[1] 王和玉 邝少轶[1] 王世雄[1] 

机构地区：[1]海南医学院药理教研室

出　　处：《海南大学学报（自然科学版）》1996年第1期53-56,共4页Natural Science Journal of Hainan University

摘　　要：老板口服液急性毒性实验，小鼠灌胃剂量达４０ｇ／ｋｇ时，未出现毒性症状和死亡现象．腹腔注射给药ＬＤ５０为１１．５６ｇ／ｋｇ．大鼠长期毒性实验分别灌胃给药１０ｇ／ｋｇ、５ｇ／ｋｇ和２．５ｇ／ｋｇ，连续６周．各组无动物死亡．动物外观、体重增长、血象、肝肾功能及各脏器指数与对照组无明显差异．脏器组织检查高剂量组１３只大鼠中有２只大鼠少量肝细胞脂肪样变．但留存动物于停药３周后，病检均正常．提示老板口服液临床口服用药安全范围较大．The authors have studied the acute and chronic toxicological actions of Laoban oralliquid. The acute toxicity was tested on Kunming mice, the maximum tolerance dose is 40 g/kgand the ip LD50 is 11. 56 g/kg. The chronic toxicity test with SD rats (ig 10, 5. 0 and 2. 5 g/kgrespectively) has showed no death and caused little pathological change in their organs except forthe fatty change in parts of the liver cells in two rats with 10 g/kg. There was no obvious changein blood routine test GPT, creatinine and nitrogen of urea of its blood after each of 21 and 42day's treatments. After 21 days of withdrawing, no pathological changes have been found.

关 键 词：老板口服液 急性毒性 长期毒性 保健药品 毒性 

分 类 号：R977.9[医药卫生—药品]