丁螺环酮缓释片的制备及其体外释放度的研究  

Preparation and in vitro release of buspirone sustained-release tablets

作　　者：蒋青锋[1] 陈志良[1] 陈建海[1] 阎玺庆[1] 曾煦欣[1] 林柏[1] 

机构地区：[1]南方医科大学附属南方医院药学部,广州501505

出　　处：《中国新药杂志》2007年第2期147-149,共3页Chinese Journal of New Drugs

基　　金：广东省科技计划项目(2002C30103)

摘　　要：目的:研制丁螺环酮缓释片的最佳处方并考察其释放度。方法:以丁螺环酮为模型药物,新型载体材料聚己内酯(PCL)和羟丙基甲基纤维素(HPMC)为骨架材料,湿法制粒压制丁螺环酮缓释片,测定药物的体外释放度,以拟合方程的相关系数r,T25,T50,Td和T80等质量评价指标来进行处方筛选。结果:根据初步筛选的最佳处方制备的缓释片释放曲线符合Higuchi方程,24 h释药超过90%。结论:以PCL和HPMC为骨架材料,能制备出释药24 h的丁螺环酮缓释片。Objective： To study optimal formulation and the release behavior of buspirone susrained-release （ SR ） tablets. Methods： Using poly-8-caprolactone （ PCL ） and hydrophilic polymers hydroxypropyl methylcellulose （HPMC） as the matrix materials, buspirone sustained-release tablets were prepared by the wet granule compression. The optimal formulation of buspirone SR tablets was assessed based on a fitted regressive equation with correlation coefficients r, T25, T50, Td and T80. Results： The release behavior of the optimal buspirone SR tablets obeyed the Higuchi equation. The release rate of the buspirone SR tablets was more than 90 percent within 24 h. Conclusion： The buspirone SR tablets were achievable.

关 键 词：丁螺环酮 聚已内酯 缓释片 体外释放度 

分 类 号：R943.41[医药卫生—药剂学] R971.4[医药卫生—药学]