氟比洛芬酯与曲马多用于腹腔镜子宫切除术后静脉镇痛  

Comparison of postoperative analgesia with flurbiprofen axetil versus tramadol in patients undergoing laparoscopically hysterectomy

作　　者：许睿[1] 张庆国[1] 刘辉[1] 曾繁荣[1] 徐世元[1] 

机构地区：[1]南方医科大学珠江医院麻醉科,广州510282

出　　处：《中国新药杂志》2007年第2期161-163,共3页Chinese Journal of New Drugs

摘　　要：目的:比较氟比洛芬酯与曲马多持续静脉镇痛用于妇科腹腔镜子宫切除术后的临床效果。方法:择期行腹腔镜子宫切除术患者40例,随机分为氟比洛芬酯和曲马多两组,每组20例。氟比洛芬酯组于手术结束前半小时静脉注射氟比洛芬酯50 mg,镇痛泵内加入氟比洛芬酯200 mg,并用生理氯化钠溶液稀释至100 mL。曲马多组于手术结束前半小时静脉注射曲马多100 mg,镇痛泵内加入曲马多1 000 mg,并用生理氯化钠溶液稀释至100mL。两组应用PCA镇痛(0.5 mL.次-1,2 mL.h-1)。术后两组行疼痛评分(BCS)及观察不良反应。结果:氟比洛芬酯组与曲马多组术后BCS评分及不良反应发生率无统计学差异。结论:腹腔镜子宫切除术术后应用氟比洛芬酯静脉持续镇痛,其效果确切,不良反应少,与曲马多相近。Objective：To assess the efficacy and safety of persistent analgesia with fiurbiprofen axetil versus tramadol in patients undergoing laparoscopically hysterectomy. Methods： 40 patients undergoing laparoscopically hysterectomy were randomly administered with one of two intravenous anesthesics： flurbiprofen axetil （50 mg, n =20） or tramadol （100 mg, n =20） 30 minutes prior to the termination of the surgery. Both groups received postoperative PCA （0.5 mL each time, 2 mL·h^-1 ） as analgesia. The efficacy was assessed based on pain scores （BCS） and the safety was evaluated based on the incidence of adverse events. Results： No significant difference of pain scores （BCS） and incidence of AEs between both treatment groups was found. Conclusion： Flurbiprofen axetil offers an alternative option for the patient-controlled analgesia of postoperative pain.

关 键 词：氟比洛芬酯 曲马多 镇痛 腹腔镜子宫切除术 

分 类 号：R969.4[医药卫生—药理学] R971.1[医药卫生—药学]