How should renin-angiotensin system blockade be applied in chronic kidney disease for optimal renal protection?  

作　　者：ZHANG Xun HOU Fan-fan 

机构地区：[1]Division of Nephrology, Nanfang Hospital, Southern MedicalUniversity, Guangzhou 510515, China

出　　处：《Chinese Medical Journal》2007年第3期243-245,共3页中华医学杂志（英文版）

基　　金：the National Nature Science Foundation (No. 30330300)

摘　　要：Chronic kidney disease （CKD） is a significant interactive disease in patients with diabetes,hypertension, and cardiovascular disease with major morbidity and mortality consequences and high costs to the healthcare system. CKD is characterized by a gradual loss of renal function. In most parts of the world, once end-stage renal disease （ESRD） occurs, patients who do not have access to maintenance dialysis or kidney transplantation would simply die. The data reported in the registry of the Chinese Society of Nephrology indicate that 41 000 ESRD patients were receiving dialysis in 1999, accounting for only 5% of the total population requiring renal replacement therapy.2 Delaying the progression of CKD to ESRD is an essential management goal for the clinical practice, particularly in developing countries.Chronic kidney disease （CKD） is a significant interactive disease in patients with diabetes,hypertension, and cardiovascular disease with major morbidity and mortality consequences and high costs to the healthcare system. CKD is characterized by a gradual loss of renal function. In most parts of the world, once end-stage renal disease （ESRD） occurs, patients who do not have access to maintenance dialysis or kidney transplantation would simply die. The data reported in the registry of the Chinese Society of Nephrology indicate that 41 000 ESRD patients were receiving dialysis in 1999, accounting for only 5% of the total population requiring renal replacement therapy.2 Delaying the progression of CKD to ESRD is an essential management goal for the clinical practice, particularly in developing countries.

关 键 词：renin-angiotensin system blockade chronic kidney disease 

分 类 号：R692[医药卫生—泌尿科学]