脐血IGF-1及IGFBP-3与胎儿生长发育的关系研究  

Levels of umbilical IGF-1 and IGFBP- 3 in human fetal growth and development

作　　者：陈日玲[1] 陈新景[2] 蔡康荣[3] 唐兰芬[1] 

机构地区：[1]广东医学院附属医院儿科,广东湛江524001 [2]广东医学院附属医院妇产科,广东湛江524001 [3]广东医学院中心实验室,广东湛江524001

出　　处：《临床儿科杂志》2007年第2期125-127,共3页Journal of Clinical Pediatrics

摘　　要：目的探讨胰岛素样生长因子-1(IGF-1)及胰岛素样生长因子结合蛋白-3(IGFBP-3)与胎儿宫内生长发育的关系。方法将新生儿根据出生体重与胎龄的关系分为大于胎龄儿(LAG)、适于胎龄儿(AGA)、小于胎龄儿(SGA)三组,分别测定三组新生儿出生时身长、体重及胎盘重量,同时取脐血采用ELISA法测定IGF-1及IGFBP-3水平。结果(1)三组新生儿出生时身长、体重及胎盘重量3个指标比较差异均有统计学意义(P均< 0．05)。②脐血IGF-1及IGFBP-3水平在SGA、AGA、LGA三组间比较,LGA组>AGA组>SGA组,各组间比较差异均有统计学意义(P均<0．05)。③胎儿发育的重要指标出生体重、身长及胎盘重量与IGF-1及IGFBP-3水平均呈正相关。结论IGF-1及IGFBP-3与胎儿生长发育密切相关,对胎儿的生长发育起重要的调节作用。Objectives To study the relationship between fetal development and insulin-like growth factor-1 （ IGF- 1 ） and IGF binding protein - 3 （ IGFBP- 3） levels at birth. Methods The neonates were divided into three groups according to birth weight and gestational age into large-for-gestational age （LGA）, appropriate-for-gestational age （AGA） and small- for-gestational age （SGA） . The birth weight, height of the newborns and placental weight were measured. The levels of IGF-1 and IGFBP-3 in the umbilical cord serum were assayed by ELISA. Results There were significant differences in birth weight, height and placental weight among three groups （P 〈 0.05） . There were significant differences in the levels of IGF-1 and IGFBP-3 among all the three groups （P 〈 0.05） . Both levels were highest in LGA group 〉 AGA group 〉 SGA group. There was positive correlation between levels of IGF- 1 and IGFBP-3 and growth parameters, including birth weight, height and placental weight. Conclusions Cord serum levels of IGF- 1 and IGFBP-3 are correlated closely with growth parameters and may play an important role in the regulation of fetal growth.

关 键 词：胰岛素样生长因子-1 胰岛素样生长因子结合蛋白-3 大于胎龄儿 适于胎龄儿 小于胎龄儿 

分 类 号：R714.5[医药卫生—妇产科学]