胸腺内注射异基因脾细胞对移植心存活的影响  

Effect of intrathymic injection of xenogenic spleen cells and cyclosporine on the survival of heart grafts

作　　者：夏仁品[1] 夏穗生[2] 姜汉英[2] 杨萍[2] 

机构地区：[1]同济医科大学93级 [2]同济医院器官移植研究所

出　　处：《中华器官移植杂志》1996年第4期155-157,共3页Chinese Journal of Organ Transplantation

摘　　要：我们进行胸腺内注射脾细胞抗原诱导移植耐受的实验研究，将ＳＤ大鼠预注射脾细胞４０７天后，行异位同种以及移植，术后１周每日腹腔注射环孢素Ａ１０ｍｇ／ｋｇ。胸腺内脾细胞注射联合短期使用ＣｓＡ组的移植心平均存活勘胶对照组显著延长，且抗原量为２．５×１０＾７脾细胞来诱导耐受的效果为好。This study examined the role of intrathymic injection of xenogenic spleen cells in induction of donor-specific unresponsiveness to heart allograft in Rat.SD Rats received in- trathymic injection of xerogenic spleen cell of Wistar Rats 7 days prior to heterotopic Wistar car- diac transplantation.In addition,cyclosporine (CsA) was given for 7 days (10 mg/kg/day) by peritoneal injection (i.p.).Intrathymic injection of spleen cells combined with short course of CsA treatment could significantly prolong graft.Our results confirmed the role of the thymus as a priv- ileged site for the induction and maintenance of specific immunological unresponsiveness to organ allografts.

关 键 词：免疫耐受 心脏移植 异基因脾细胞 存活 

分 类 号：R654.2[医药卫生—外科学]