大动脉僵硬度与冠心病相关性研究  

Correlation between arterial stiffness and coronary disease

作　　者：朱淑贤[1] 钱菊英[2] 葛均波[2] 许澎[1] 周亚刚[1] 伍旭升[1] 

机构地区：[1]复旦大学附属上海市第五人民医院心内科,200240 [2]复旦大学附属中山医院心血管研究所

出　　处：《中华老年医学杂志》2007年第1期9-12,共4页Chinese Journal of Geriatrics

摘　　要：目的 探讨颈一股动脉脉搏传导速度（C-F PWV），分析大动脉僵硬度和冠心病的相关性。方法 408例行冠状动脉造影的患者，男313例，女95例。均采用Complior SP测量系统测量C-F PWV。记录血流动力学指标和心血管危险因素。冠状动脉病变的严重程度用冠状动脉病变的血管支数表示，比较不同严重程度冠心病患者的C-F PWV值，同时对C—F PWV与冠脉复杂病变的相关性进行评估。结果 冠心病组年龄明显大于对照组[分别为（65.6±9.5）岁与（59.8±10.2）岁，P〈0．01；。C-F PWV在校正了年龄、性别、高血压、高血脂和糖尿病等因素后经Logistic回归分析后，仍与冠心病的存在显著相关，分别为（10.3±1.79）与（12.8±3．1）m／s，P〈0．01。C-F PWS值的升高和冠脉病变的严重程度相关（P〈0.01），同时伴有更多的复杂病变，如完全闭塞病变，弥漫性病变和钙化病变。结论 C-F PWV是一个判断冠心病存在及其严重程度的独立预测指标。Objective To investigate the correlation between arterial stiffness and coronary artery disease（CAD）. Methods The carotid-femoral pulse wave velocity （C-F PWV） was used as the index of arterial stiffness, and was measured by using complior SP in 408 patients （313 males, 95 females） who underwent coronary angiographic examination （CAG）. Hemodynamic data were collected and cardiovascular risk factors were analyzed. The number of major coronary arteries having stenosis was indicated as the index of the stenosis degree, and the correlation between arterial stiffness and CAD was analyzed. Results Patients with CAD were significantly older（65.6±9.5） years than the control（59. 8±10. 2） years, P〈0. 01. After adjustments for probable risk factors, such as age, gender, presences of hypertension,hyperlipidemia and diabetes, logistic multivariate analysis showed that C-F PWV significantly correlated with coronary artery disease （ P〈0. 01）. The higher the C-F PWV, the more serious the coronary artery disease （P〈0. 01）. Special CAG findings such as the presence of complete occlusion, diffuse changes or calcification were found more often. Conclusions High C-F PWV is an independent predictor for the presence and severity of CAD.

关 键 词：冠状动脉疾病 动脉硬化 脉搏 

分 类 号：R686[医药卫生—骨科学]