小剂量替加色罗治疗动力障碍型功能性消化不良的临床观察  

The effect of low-dose tegaserod on dysmotility-like dyspepsia

作　　者：林金坤[1] 肖英莲[1] 王思云[2] 杨莉[1] 陈旻湖[1] 

机构地区：[1]中山大学附属第一医院消化科,广州510080 [2]中山大学附属第一医院放射科,广州510080

出　　处：《中华消化杂志》2007年第1期39-42,共4页Chinese Journal of Digestion

摘　　要：目的评价小剂量替加色罗对动力障碍型功能性消化不良（d-FD）患者的疗效。方法符合功能性胃肠病罗马Ⅱ诊断标准的d-FD患者，随机接受替加色罗3mg每天2次（T组，43例）或莫沙必利5mg每天2次（M组，43例）治疗。同时选择性别及年龄相匹配的15名志愿者作为对照组。用视觉模拟标尺（visual analogue scale，VAS）0～10分评定症状严重度。计算治疗前1周及治疗后1、2周患者的总体FD症状、饱胀、早饱、暖气、恶心等症状积分；并随机分别从各组中选择15例于治疗前及治疗2周时行钡条胃排空试验及饱餐试验。结果与基线期比较，两组患者治疗l周及2周时各项症状积分均呈逐渐下降趋势（P〈0．05）；治疗2周时，T组患者的FD总体症状感觉积分下降值（22．9±10．0）和治疗有效率（62．8％）与M组（分别为18．7±10．4和5．8％）之间差异无统计学意义（P值均〉0．5）；T组早饱症状积分下降值（24．0±12．4）和治疗有效率（76．7％）均高于M组（分别为9．6±8．1和16．3％，P值均〈0．01）。饱胀、暖气及恶心的治疗有效率两组间差异均无统计学意义（P〉0．05）。胃排空钡条数在治疗前两组间差异无统计学意义（P〉0．05），但均少于正常对照组（P〈0．01），治疗后两组均明显增多（P值均〈0．01），但两组间差异无统计学意义（P〉0．05）。治疗前进餐最大耐受容量两组间差异无统计学意义（P〉0．05），但均明显少于正常对照组（P〈0．05）。治疗后各组进餐量最大耐受容量均明显增多（P〈0．05）；T组治疗后的进餐最大耐受容量及治疗后进餐量增加值均显著高于M组（P〈0．01）。结论替加色罗治疗d—FD有效，对改善早饱症状及增加试餐进餐量优于莫沙必利。Objective To assess the efficacy of low-dose tegaserod in treatment of dysmotility-like functional dyspepsia（d-FD）. Methods Eithty-six patients with d-FD （fulfilled Rome Ⅱ criterion） randomly received either tegaserod 3 mg twice daily（T group, 43 patients） or mosapride 5 mg twice daily （M group, 43 patients） for 2 weeks. The symptoms including patients＇perception of overall FD symptoms, fullness, early satiety, belching, and nausea were evaluated daily from one-week pretreatment as baseline to second-week of treatment using visual analogue scale（VAS, 0-10 scoring）. Gastric emptying of solid food was examined using radiopaque markers and the satiety test were done by drinking ensure nutrient liquid before treatment and at the end of the 2 weeks in fifteen patients from T group and in fifteen patients from M group, respectively. Results Comparing with baseline period, the scores of every symptoms decreased gradually within 2-week treatment in both groups （P 〈 0.01）. In the secondweek period, the declined value of scores of patients＇perception of overall FD symptoms did not differ significantly between T group and M group （22.9 ± 10.0 vs 18.7 ± 10.4, P 〉 0.05）, and the efficacy rate of treatment for patients＇perception of overall FD symptoms in T group and M group were 62.8% and 55.8%, respectively （P〉 0.5）. The declined value of scores of early satiety in T group was greater than that in M group （24.0 ± 12.4 vs 9.6 ± 8.1, P 〈 0.01）, and the efficacy rate of early satiety in T group was higher than that in M group （76.7% vs 16.3%, P 〈 0. 001）. The average number of barium strip expelled from stomach were 3（0--16） in T group and 4（0--14） in M group （P 〉 0.05） before treatment and was increased significantly to 18（2--20） （P 〈 0.01） and 16（4--20） （P 〈 0.01）, respectively, after treatment. There were no significant difference between T group and M group （P 〉 0.05） after treatment. The maximum tolerated volume of food（

关 键 词：胃肠疾病 药物治疗 消化不良 

分 类 号：R686[医药卫生—骨科学]