替米考星、红霉素体外诱导猪胸膜肺炎放线杆菌耐药性的初步研究  

Resistance induction of Actinobacillus pleuropneumoniae by tilmicosin and erythromycin in vitro

作　　者：王绍琛[1] 王桂琴[1] 吴聪明[1] 沈建忠[1] 

机构地区：[1]中国农业大学动物医学院,北京100094

出　　处：《畜牧与兽医》2006年第11期7-9,共3页Animal Husbandry & Veterinary Medicine

摘　　要：采用微量稀释法测定了替米考星和红霉素对5株临床分离猪胸膜肺炎放线杆菌(App)的最小抑菌浓度,并用药物浓度递增法体外诱导App对两种药物的耐药性。结果表明替米考星和红霉素对App都具有很高的体外抑菌活性;经15代诱导,App对替米考星的最高耐受浓度没发生明显变化,而对红霉素的最高耐受浓度有了较大程度的提高,表明App对替米考星不易产生耐药,而对红霉素可缓慢产生耐药。试验结果提示替米考星是治疗App感染的理想药物。The minimum inhibitory concentration values of tilmicosin and erythromycin were determined in 5 clinical isolates of Actinobacillus pleuropneumoniae. Antibiotic-resistant mutants were selected in vitro from 5 susceptible isolates of A. pleuropneumoniae by serial passages in stepwise concentrations of tilmicosin and erythromycin. Resistance to erythromycin developed slowly, whereas resistance to tilmicosin didn＇t develop after 15 passages. The results showed that tilmicosin was an ideal drug for controlling the pneumonia caused by A. pleuropneumoniae in pigs.

关 键 词：猪胸膜肺炎放线杆菌 替米考星 红霉素 耐药性 

分 类 号：S858.286.4[农业科学—临床兽医学]