聚L-乳酸/β-磷酸三钙复合骨支架材料成型工艺优化研究  

Study on molding technology optimization of preparing porous poly(L-lactic acid)/β-tricalcium phosphate composite scaffold materials

作　　者：许秀娟[1] 尹光福[1] 王科锋[1] 唐小红[1] 康云清[1] 

机构地区：[1]四川大学材料科学与工程学院,成都610064

出　　处：《化工新型材料》2006年第12期77-80,共4页New Chemical Materials

基　　金：国家863项目(2002AA326080);教育部优秀青年教师基金(2002123);四川省杰出青年基金(2001-2)资助课题

摘　　要：利用溶剂自扩散-模压成型-粒子沥滤法制备聚L-乳酸（PLLA）／β-磷酸三钙（β-TCP）复合多孔支架材料，采用正交设计对成型工艺进行了优化，对支架进行了形貌观察、力学强度和孔隙率大小测试。结果表明：当PLLA：β-TCP=1：2，成型压力5MPa，致孔剂粒径125～400μm，用量80％（wt）时，制备的支架材料孔结构三维贯通，抗压强度为4．45MPa、孔隙率为60．7％，满足骨组织工程支架材料要求。Porous poly（L-lactic acid）（PLLA）/β-tricalcium phosphate（β-TCP） composite scaffold was fabricated by using the method of solvent self-diffusion, compression molding and leaching. The orthogonal design was used to optimizing the molding technology. Composite scaffold was characterized by SEM observation, the mechanical strength and porosity were tested. The results showed that the pores structure of composite scaffold was interconnected, the compressive strength was 4. 45MPa and porosity was 60. 7% ,which was fabricated under technology that PLLA：β-TCP = 1 ： 2, molding compression was 5MPa, the particle size of porogen was 125～400μm and percentage content was 80 % （wt）. These properties could meet the needs of bone tissue engineering.

关 键 词：多孔支架 溶剂自扩散 正交设计 工艺优化 

分 类 号：R318.08[医药卫生—生物医学工程]