1,4-二氢吡啶衍生物的合成方法改进  

Improvement on the Synthesis of 1,4-Dihydropyridine Derivatives

作　　者：王建平[1] 杜美菊[2] 付永举[3] 王建革[1] 李宁[1] 郑爱霞[1] 

机构地区：[1]洛阳师范学院化学系,河南洛阳471022 [2]商丘师范学院化学系,河南商丘476000 [3]河南科技大学化工与制药学院,河南洛阳471003

出　　处：《合成化学》2007年第1期42-45,共4页Chinese Journal of Synthetic Chemistry

基　　金：洛阳师范学院重点学科资助课题(2004YZK90)

摘　　要：采用改进的Hantzsch反应,在氮气保护下的封闭体系中回流芳香醛、乙酰乙酸乙酯和NH4HCO3,合成了1,4-二氢吡啶衍生物(1a^1d),其结构经1HNMR,IR和元素分析确认。用XRD测定了1b的晶体结构。1,4-Dihydropyridine derivatives （1a～1d） were synthesized by improved Hantzsch reaction of aromatic aldehyde, ethyl acetoacetate and NH4HCO3 in a closed system filled with nitrogen gas under refluxing. The structures were confirmed by ^1H NMR, IR and elemental analysis. The crystal structure of 1b was determined by XRD.

关 键 词：二氢吡啶 Hantzsch反应 方法改进 合成 

分 类 号：O626.32[理学—有机化学]