TDI技术评价卡维地洛对高血压患者左室舒张功能的影响  

Assessment of Efficacy of Carvedilol on Left Ventricular Diastolic Function in Hypertensive Patients

作　　者：赵玉英[1] 卫亚利[1] 李俊峡[1] 汝磊生[1] 智光[2] 

机构地区：[1]解放军白求恩国际和平医院心血管内科,石家庄050082 [2]解放军总医院心血管内科,北京100853

出　　处：《华北国防医药》2007年第1期56-58,共3页Medical Journal of Beijing Military Region

摘　　要：目的:应用组织多普勒显像(TDI)技术评价卡维地洛对高血压患者左室舒张功能的影响。方法:对30例高血压给予卡维地洛治疗24周,治疗前、治疗后12周、24周用TDI技术测量左室收缩期二尖瓣环平均舒张早期运动速度(Ea)、舒张晚期运动速度(Aa)及Ea/Aa,并与血流多普勒指标E波速度(E)、A波速度(A)、E/A进行比较,观察降压效果及对左室舒张功能的影响。结果:卡维地洛治疗12周后收缩压(SBP)、舒张压(DBP)、心率(HR)均较治疗前下降(P<0.05),Ea、Ea/Aa均较治疗前升高(P<0.05),治疗24周后E、E/A较治疗前升高(P<0.05),Aa较治疗前降低(P<0.05),Ea、Ea/Aa有进一步改善的趋势(P<0.05)。结论:TDI技术在评价左室舒张功能方面较二尖瓣血流频谱更敏感;卡维地洛对轻、中度高血压具有良好的降压作用,且能改善患者左室舒张功能。Objective：To assess the effect of Carvedilol on the left ventricular diastolic function of hypertensive patients with tissue Doppler imaging （TDI）. Methods： A total of 30 hypertension patients were treated with Carvedilol for 24 weeks. At the baseline, after 12 and 24 weeks of treatment, the patients were examined by TDI and pulsed Doppler echocardiography, and Ea ,Aa, Ea/Aa, E, A and E/A were recorded. Results：After Carvedilol treatment, SBP,DBP and heart rate decreased significantly. After 12 weeks of treatment with Carvedilol, Ea and Ea/Aa increased significantly without changes in E, E/A and A. After 24 weeks of further treatment with Carvedilol, E, E/A also increased significantly. Conclusion ：Tissue Doppler imaging is more reliable than pulsed Doppler echocardiography in the assessment of the left ventricular diastolic function. Carvedilol is an effective antihypertensive drug and can improve the left ventricular diastolic function.

关 键 词：高血压 超声心动描记术 多普勒 左室舒张功能 卡维地洛 

分 类 号：R544.1[医药卫生—心血管疾病]