磷脂酰胆碱抗氧化效应及对遗传损伤的保护作用  

A study of antioxdation and protective effect of genetical damage on phosphatidylcholine

作　　者：曹新[1] 黄瑾[1] 刘仁海[1] 

机构地区：[1]石河子医学院,厦门大学生物系

出　　处：《中国优生与遗传杂志》1996年第6期25-26,共2页Chinese Journal of Birth Health & Heredity

摘　　要：磷脂酰胆碱５００ｍｇ／ｋｇ灌胃２０日可使Ｏ_３环境中的小鼠超氧化物歧化酶（ＳＯＤ）活性显著增强，血浆丙二醛（ＭＤＡ）含量及外周血正染红细胞（ＮＣＥ）微核率明显下降。结果提示：磷脂酰胆碱具有抗氧化作用及拮抗自由基造成遗传的损伤。进一步证实了自由基在微核形成中具有重要意义。Phosphatidylcholing(ig,500 mg/kg×20d)could elevate significantly the activity of SOD and reduced remarkably the concentration of MDA and the frequcency of NEC micrcnuleci in mice in ozone,The results indicated that phosphatidylcholine possessed ability of antioxidation and supressive effect on the mutagenic activity of the free radical.This study confirmed that the free radical production plays an important rolein the micronucleus fromation.

关 键 词：磷脂酰胆碱 抗氧化效应 遗传损伤 药理学 

分 类 号：R965[医药卫生—药理学] R977.9[医药卫生—药学]