6,7-二氢-6-甲基-3-甲硫基吡喃[4,3-c]吡唑-4-(2H)-酮衍生物的合成及生物活性  

Synthesis and Bioactivity of 1(2)-Aryl-6,7-dihydro-6-methyl-3-methylthiopyrano[4,3-c]pyrazol-4-(2H)-ones

作　　者：邢媛媛[1] 郝静君[1] 郭少雄[1] 王有名[1] 

机构地区：[1]南开大学元素有机化学国家重点实验室,天津300071

出　　处：《精细化工中间体》2007年第1期19-22,共4页Fine Chemical Intermediates

基　　金：国家自然科学基金青年基金资助项目(20302003)

摘　　要：6-甲基-5,6-二氢吡喃-2,4-二酮和二硫化碳、碘甲烷缩合得到5,6-二氢吡喃-2,4-二酮的二硫缩醛化合物,然后和取代肼反应得到1位取代和2位取代6,7-二氢-6-甲基-3-甲硫基吡喃[4,3-c]吡唑-4-(2H)-酮衍生物。其化学结构通过单晶X衍射、1HNMR、13CNMR、元素分析证实。生物活性测试结果初步表明,该类化合物表现出一定的杀菌和对前列腺癌细胞PC3的抑制活性。3-（Bismethylthio）methylene-5,6-dihydro-6-methyl-2H-pyran-2,4-diones were obtained by reacting 5,6- dihydro-6-methyl-2H-pyran-2,4-diones with carbon disulfide, methyl halides, which were also reacted with substituted hadrozines to synthesize 1 （2）-Aryl-6,7-dihydro-6-methyl-3-methylthiopyrano [4,3-c]pyrazol-4-（2H）- ones. Their structures were confirmed by ^1H NMR, X diffraction and elemental analysis. Their fungicidal and anticancer activities were also tested.

关 键 词：6 7-二氢-6-甲基-3-甲硫基吡喃[4 3-c]吡唑-4-(2H)-酮 杀菌 抗癌 

分 类 号：TQ455.4[化学工程—农药化工]