3-氯-4-(2-溴甲基-4-甲基-1,3-二恶戍烷-2-基)苯基-4′-氯苯基醚的合成  

Synthesis of 3-Chloro-4-(2-bromomethyl-4-methyl-1,3-dioxolane-2-yl)phenyl-4′-chlorophenyl Ether

作　　者：熊莉莉[1] 陶贤鉴[1] 黄超群[1] 胡智红 谢伟胜[1] 

机构地区：[1]湖南化工研究院,湖南长沙410007 [2]湖南海利化工股份有限公司,湖南长沙410007

出　　处：《精细化工中间体》2007年第1期28-29,40,共3页Fine Chemical Intermediates

摘　　要：3-氯-4-(2-溴甲基-4-甲基-1,3-二恶戍烷-2-基)苯基-4′-氯苯基醚是杀菌剂苯醚甲环唑的一个重要中间体。以2-氯-4-(4-氯苯氧基)-苯乙酮为起始原料,采用溴化和合环同时进行的合成工艺制得该化合物,收率90%,产品含量95%。优化了反应条件,简化了操作。3 -Chloro -4 - （2 -bromomethy1-4 - 1,3 -dioxolane -2 -yl）pheny1-4＇ -chlorophenyl ether is an important intermediate of fungicide difenoconazole, 3 -chloro -4 -（2 -bromomethyl -4 -1,3 -dioxolane -2 -yl）phenyl -4＇ - chlorophenyl ether, which was prepared by bromination and ketal reaction of 2-chloro-4-（4-chlorophenoxy）- aectophenone in one step pathway. The yield was 90%, and purity 95%. The process had several advantages of facile reaction conditions, convenient operation and cheap reagents.

关 键 词：杀菌剂 3-氯-4-(2-溴甲基-4-甲基-1 3-二恶戍烷-2-基)苯基-4’-氯苯基醚 苯醚甲环唑 溴化 缩 酮化 

分 类 号：S482.2[农业科学—农药学]