普通外科病人真菌败血症的临床研究  

Clinical analysis of patients with fungal septicemia in general surgery department

作　　者：顾军[1] 任建安[1] 李维勤[1] 李宁[1] 

机构地区：[1]南京军区南京总医院普通外科,江苏南京210002

出　　处：《中国实用外科杂志》2007年第2期141-143,共3页Chinese Journal of Practical Surgery

摘　　要：目的探讨普通外科真菌败血症的发生特点、病原菌的种类及防治策略。方法回顾性分析2001年3月至2005年12月间南京军区南京总医院普通外科收治的94例真菌败血症病人的易感因素、病原学特点及治疗效果。结果易感因素主要为使用广谱抗生素、中心静脉插管、全胃肠外营养、入住重症监护病房。94例病人分离出94例菌株。非白色念珠菌是主要致病真菌。94例经抗真菌治疗者中37例死亡。结论真菌败血症多发生在存在腹腔感染病人。念珠菌属是主要致病真菌,其中以非白色念珠菌为主。对高危病人应重视病原学检查及药物敏感性测定,消除易感因素,及时合理选用抗真菌药物和肠内营养有望进一步改善预后。Objective To study the clinical characteristics of fungal species,therapy and prevention of fungal septicemia. in general surgery department. Methods A retrospective analysis of predisposing factors, distribution of fungi, treatment and outcome of 94 patients with fungal septicemia from March 2001 to December 2005 was done. Results The most frequent predisposing factors were the use of broad spectrum antibiotics, indwelling central intravenous catheter, total parenteral nutrition, admission to intensive care unit. 94 strains of fungal isolated from 94 patients. Candida was the predominantly pathogenic organism. Non-Candida. albicans species were the most frequently isolated strains. Thirty-seven cases were dead among the 94 cases being treated with antifungal drugs. Conclusion Fungal septicemia usually occurred in severe intra abdominal infectious patients. Non Candida albicans species are the major pathogens. Removing predisposing factors,isolation of pathogens,antibiotic susceptibility testing and correct choice of antifungal agents and enteral nutrition in high risk patients are important measurements to reduce the incidence and mortality of fungal septicemia.

关 键 词：真菌败血症 肠内营养 腹腔感染 

分 类 号：R6[医药卫生—外科学]