辛伐他汀作用下成骨细胞骨重建相关基因的研究  

The influence of simvastatin on the related bone remolding genes of osteoblast

作　　者：胡飞[1] 张雪洋[1] 周磊[1] 

机构地区：[1]广东省口腔医院南方医科大学附属口腔医院,广州市510280

出　　处：《实用医学杂志》2007年第4期454-456,共3页The Journal of Practical Medicine

基　　金：广东省自然科学基金资助项目(编号:32569);广东省医学科学技术研究基金资助项目(编号:A2005114)

摘　　要：目的:研究辛伐他汀对小鼠成骨细胞骨重建相关基因表达的影响,探讨其促进骨重建作用的分子机制。方法:辛伐他汀处理小鼠成骨细胞后,采用基因芯片检测骨重建相关基因的表达改变。结果:辛伐他汀处理小鼠成骨细胞后,基因芯片筛选出与骨重建相关的差异表达基因9条,明显上调的有5条(Ratio>2.0),明显下调的有4条(Ratio<0.5)。结论:辛伐他汀促进骨重建作用的机制不仅涉及骨形成相关基因,而且与抑制骨吸收的相关基因关系密切。Objective To explore the influence of simvastatin on the related bone remolding genes of osteoblast and its molecular mechanism of improving bone remolding. Methods After treated with simvastatin, the expression of bone remolding genes of mouse osteoblast was detected using gene chip. Results There were nine differentially expressed genes related to bone remolding, with five up-regulated and four down-regulated genes. Conclusion The action of mechanism of simvastatin in improving bone remolding is not only related to the ossification genes, but also closely to the relevant genes responsible for the inhibition of bone resorption.

关 键 词：成骨细胞 骨重建 辛伐他汀 基因表达 

分 类 号：R96[医药卫生—药理学]