前列腺素E_1治疗新生儿完全性大动脉转位的疗效  

Curative Effect of Prostaglandin E_1 in Treating Neonates with Complete Transposition of Great Arteries

作　　者：余波[1] 林振浪[1] 李莎莎[1] 张姿英[1] 

机构地区：[1]温州医学院附属育英儿童医院新生儿科,浙江温州325027

出　　处：《实用儿科临床杂志》2007年第1期57-58,共2页Journal of Applied Clinical Pediatrics

摘　　要：目的 了解前列腺素E1治疗新生儿完全性大动脉转位时在维持血氧饱和度、延长患儿存活时间方面的作用。方法 大动脉错位患儿19例分为两组。治疗组11例采用前列地尔静脉24h持续滴注，5～20ng／（kg·min）；对照组8例采用一般治疗。用药期间监测患儿体温、血氧饱和度、心率、血压等指标。结果 治疗组血氧饱和度为（82．30±3．56）％，对照组为（67．30±4．54）％．二者比较有显著性差异（t=8．232 P=0．001），其存活时间明显长于对照组；治疗组体温、心率、血压等指标未见明显波动。结论 前列腺素E1对维持完全性大动脉转位患儿的动脉导管开放、改善血氧饱和度、延长存活时间具有良好作用。Objective To study the curative effect of prostaglandin E1 （ PGE1 ） on maintaining Sa （ O2 ） and life span in the neonates with complete transposition of the large arteries（TGA）. Methods Eleyen of 19 neonates complete TGA received continuous PGE1 with the dosage of 5 -20 ng/（ kg·min）, while the other 8 cases were set as control. The body temperature, Sa （O2 ）, heart rate and blood pressure of both groups were recorded during the trial. Results The average Sa （O2 ） in trial group was （ 82.3±3.56 ） %, which had significant difference compared with control group （t = 8. 232 P = 0.001 ）. The life span in trial group was much longer than control group. The body temperature, heart rate and blood pressure of trial group had no significant fluctuations. Conclusion PGE1 has an compkete effect on maintaining the opening of patent ductus arteriesus （PDA） in TGA patients,which can improve the Sa （O2 ） and prolong the life span.

关 键 词：前列地尔 前列腺素E1 完全性大动脉转位 婴儿 新生 

分 类 号：R722.1[医药卫生—儿科]