血红素氧合酶-1/一氧化碳系统与急性肺损伤  

Heme Oxygenase-1/Carbon Monoxide and Acute lung injury

作　　者：安莉[1] 俞森洋[1] 

机构地区：[1]中国人民解放军总医院南楼呼吸科,北京100853

出　　处：《医学综述》2007年第3期163-165,共3页Medical Recapitulate

摘　　要：血红素氧合酶-1/一氧化碳(HO-1/CO)系统在多种应激状态下诱导产生,通过抗氧化、抗炎、抗凋亡等机制发挥组织器官保护作用,基因治疗、药物诱导HO-1高表达或外源性CO可能成为治疗多种疾病的新途径。本文就HO-1/CO系统的产生、调控及在急性肺损伤中的表达和作用简要综述。Heine Oxygenase-1/Carbon Monoxide system （HO-1/CO） is induced by various stimuli and stresses, which exerts cytoprotection through antioxidation, antiinflammatory and antiapoptosis. Upregulation of HO- 1 through gene therapy and pharmacological induction as well as exogenous carbon monoxide may provide new way for future disease therapy.This article summarize HO-1/CO about its production,regulation and its expression and effect in acute lung injury.

关 键 词：急性肺损伤 血红素氧合酶-1 一氧化碳 胆红素 

分 类 号：R563[医药卫生—呼吸系统]