肝细胞生长因子和胰岛素样生长因子-1在妊高征胎盘中的表达及意义  

Significance and Expression of HGF and IGF-1 in Placenta of Pregnancy-induced Hypertension Syndrome

作　　者：张建华[1] 张延丽[1] 

机构地区：[1]山西医科大学第一附属医院,太原030001

出　　处：《医学综述》2007年第4期252-254,共3页Medical Recapitulate

摘　　要：妊娠高血压综合征(PIH)是常见的严重危害母婴健康的妊娠并发症,目前其发病机制尚不明确。近年,许多学者提出胎盘或滋养细胞缺血与PIH发病关系密切。肝细胞生长因子(HGF)及胰岛素样生长因子-1(IGF-1)被认为与滋养细胞的增殖或侵蚀有关。该文就HGF及IGF-1的生物学特性,与正常妊娠的关系及其在PIH发生、发展中的作用进行综述。Pregnancy induced hypertension syndrome（PIH） is a pregnancy complication that threatening the health of mother and infant harm seciously. The pathogenesis of PIH is unkown yet now. Recently, many researchers indicated that placental or trophoblastic ischemia is closely associated with PHI. Hepatocyte growth factor（HGF） and insulin-like growth factor-1（IGF-1） are thought to he concerned with trophoblastic proliferation and invaslon.In this review, we summarized HGF and IGF-1 about their biological features,their correlation with normal pregnancy and the significance in occurrence and development of PIH.

关 键 词：肝细胞生长因子 胰岛素样生长因子-1 妊娠高血压综合征 

分 类 号：R714.24[医药卫生—妇产科学]