3.0T磁共振脑深部核团T_2信号值与脑铁浓度相关关系研究  

Correlation study of T_2 signal values of deep brain gray nucleus and estimated iron content at 3.0 Tesla MR

作　　者：许化致[1] 孙波[2] 李建策[1] 

机构地区：[1]温州医学院附属第一医院放射科,浙江温州325000 [2]北京天坛医院神经影像中心,北京100050

出　　处：《中国临床医学影像杂志》2007年第2期81-84,共4页Journal of China Clinic Medical Imaging

摘　　要：目的:研究3.0Tesla磁共振成像正常人脑深部灰质核团(主要包括红核、黑质、苍白球、壳核、尾状核头)T2信号值与局部脑组织非色素性铁浓度的相关关系。方法:收集2004年12月～2005年5月在北京天坛医院行头颅核磁共振检查正常人T2WI1192例,其中男689例,女503例,年龄1～87岁。将年龄按5年分组,共分17组。使用Efilmworkstation2.0图形工作站测量T2WI脑深部核团和额叶皮层T2信号值,并计算脑深部核团相对额叶皮层比值R。结果:红核、黑质、苍白球、壳核R值与相应局部铁估计浓度存在直线负相关(红核P=0.001,r=-0.748;黑质P<0.001,r=-0.863;苍白球P<0.001,r=-0.965;壳核P<0.001,r=-0.816)。尾状核头部R值与铁估计值不存在直线相关(P=0.336>0.05)。结论:红核、黑质、苍白球、壳核R值可半定量反应相应部位脑组织内非色素性铁含量。Objective： To study the correlation of T2 signal values of deep brain gray nucleus and estimated iron content at 3.0 Tesla magnetic resonance machine. Materials and Methods： 1192 cases of T2WI of normal brain examined at 3.0T Siemens Trio machine in Beijing Tiantan Hospital from Dec. 2004 to May 2005 were collected （including male 689, female 503, age ranged from 1 to 87 years）. All cases were divided into 17 groups by five years. The signal values of red nucleus, substantia nigrth globus pallidus, putamen, caudate nucleus and the frontal cortex on T2WI were measured with Efilm workstation 2.0 measuring tools, the measurements were conducted three times. The ratios of T2 signal values of deep gray nucleus compared to the frontal cortex were calculated. Results： The ratios of red nucleus, substantia nigra, globus paUidus, putamen showed a strong linear correlation with estimated iron content （red nucleus P=0.001, r=-0.748, substantia nigra P〈0.001, r= -0.863, globus pallidus P〈0.001, r=-0.965, putamen P〈0.001, r=-0.816）. But there was no linear correlation between the ratio of caudate nucleus and the estimated iron content of that（P=0.336〉0.05）. Conclusion： The ratios of red nucleus, substantia nigra globus pallidus, putamen can reflect local nonheme iron content semi-quantitatively.

关 键 词：脑 铁 磁共振成像 

分 类 号：R338.2[医药卫生—人体生理学] R445.2[医药卫生—基础医学]