超声评价颈动脉粥样硬化的临床研究  

Two-diamensional and Doppler ultrasonography evaluating atherosclerosis of carotid artery

作　　者：盖永浩[1] 宋树良[2] 吴世慧[1] 宋庆达[3] 

机构地区：[1]山东省临沂市人民医院超声诊疗中心,276003 [2]上海同济医科大学附属上海东方医院超声科 [3]山东省医学影像研究所超声室

出　　处：《临床超声医学杂志》2007年第2期72-75,共4页Journal of Clinical Ultrasound in Medicine

摘　　要：目的探讨二维超声、多普勒超声及超声-生理学指标对颈动脉粥样硬化的评价。方法选取经临床确诊的颈动脉粥样硬化患者49例和正常人35例,分为观察组与对照组,进行颈总动脉(CCA)血流动力学、内-中膜厚度(IMT)及血管超声-生理学指标对照分析,确定评价颈动脉粥样硬化的可行性指标。结果①观察组左右侧CCA主干和分叉部IMT较对照组显著增厚(P<0.01);②观察组收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)、平均血流速度(MV)均降低,与对照组比较差异有统计学意义(P<0.05);③观察组的扩张系数(Dc)和顺应系数(Cc)较对照组均减低,扩张系数两组比较差异有统计学意义(P<0.05);④颈动脉主干IMT与PSV、EDV、MV、Dc之间成负相关,与相应脉压(PP)、收缩压(SBP)、CCA的收缩期内径(Ds)、舒张期内径(Dd)、动脉壁僵硬度(wall stiffness)β之间成正相关。结论高频超声检查IMT、血流动力学参数PSV、EDV、MV降低,收缩期峰值血流速度与舒张末期血流速度比值(PSV/EDV)升高,PI和RI升高,超声-生理学指标Dc和Cc减低,僵硬度的增加可作为诊断颈动脉粥样硬化较可靠指标。Objective To explore the feasibility of multi - index of ultrasound in diagnosing atheresclerosis（As） of carotid artery. Methods Forty- nine patients with As（ atheresclerosis） of carotid artery considered as observed group（OG） and 35 normal subjects as control group（ CG） were enrolled in the study. ＂The indexes of hemodynamics, intima - media thickness（IMT） and ultrasound - physiology were compared between OG and CG. Results ① IMTs of both CCAs＇ thinks and bifurcations in OG were significantly thicker than those in CG （P 〈 0.01）; ② Peak systolic velocity（PSV）, end diastolic velocity（EDV） and mean velocity（MV） were decreased significantly in OG than those in CG（ P 〈 0.05） ; ③Both distensibility coefficient（Dc） and compliance coefficient（Cc） were decreased in OG but only Dc was decreased significantly（ P 〈 0.05） ;④IMTs of both CCAs＇ thinks were of negative correlation with blood velocity and Dc but positive correlation with pulse pressure（PP）, systolic pressure（SBP）, systolic diameter（Ds）, diastolic diame- ter（Dd） and wall stiffness（β） respectively. Conclusion The high - frequency ultrasonography of IMT of CCA is a precise way to evaluate As of carotid artery and the alteration of hemodynamics（such as decreased PSV, EDV, MV and increased PSV/EDV, PI, RI） and ultrasound- physiology （such as decreased Dc, Dd and increased ~3） are helpful indexes as well.

关 键 词：超声检查 多普勒 动脉粥样硬化 内-中膜厚度 

分 类 号：R543.4[医药卫生—心血管疾病]