联合检测CEA、CA_(19-9)、CA_(50)对老年胆管癌的诊断价值  

Diagnostic value of combined detection of CEA,CA_(19-9) and CA_(50) on elderly patients with cholangiocarcinoma

作　　者：孙浩[1] 罗文军[2] 吴晓春[1] 

机构地区：[1]重庆市第三人民医院肝胆外科,重庆400014 [2]重庆医科大学附属第二医院普外科,重庆400010

出　　处：《重庆医科大学学报》2007年第3期287-289,共3页Journal of Chongqing Medical University

摘　　要：目的:探讨联合检测肿瘤标志物对老年胆管癌的诊断价值。方法:采用放射免疫法和免疫放射法对35例老年胆管癌患者和31例胆管良性疾病患者静脉血清中CEA、CA19-9和CA50进行测定。结果:诊断胆管癌血清CA19-9、CA50的敏感度较好,分别为80.00%和91.48%;血清CEA的特异度最好,为87.10%;联合检测并联法优于串联法,敏感度保持在88.64%,准确度增加。结论:联合检测肿瘤标志物对老年胆管癌的诊断具有协同作用,准确度增加,降低了漏诊率和误诊率。Objective：To explore the diagnostic value of combined detection of tumor markers on elderly patients with cholangiocarcinoma.Methods：Radioimmunoassay and immunoradiometricassay were adopted to detect CEA,CA19-9 and CA50 in venous serum of 35 elderly patients with cholangiocarcinoma and 31 cases of benign bile duct disease.Results：CA19-9 and CA50 in serum had better sensitivity in diagnosing cholangiocarcinoma,and the rates were 80.00% and 91.48% respectively.CEA in serum had the best specificity with the rate as 87.10%.Parallel testing was superior to series testing in combined detection with the sensitivity remaining as 88.64% and the accuracy promoted.Conclusion：The combined detection of tumor markers had cooperative function in diagnosing the elderly patients with chola ngiocarcinoma,with the accuracy promoted,and the rates of missed diagnosis and misdiagnosis lowered.

关 键 词：胆管癌 肿瘤标志物 CEA CA19-9 CA50 

分 类 号：R446.11[医药卫生—诊断学] R735.8[医药卫生—临床医学]